Publications

    PUBLICATION

    Breast cancer remodels lymphatics in sentinel lymph nodes 

    Dominik Eichin et al.

    Nat Commun. 2025 Nov 17;16(1):10056. doi: 10.1038/s41467-025-64981-z.

    Published on November 17, 2025

    Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis Read more

    PUBLICATION

    LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation 

    Ubaid Ullah Kalim et al.

    iScience. 2025 Oct 15;28(11):113779. doi: 10.1016/j.isci.2025.113779. eCollection 2025 Nov 21.

    Published on November 17, 2025

    Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and Read more

    PUBLICATION

    Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration 

    António G G Sousa et al.

    Nucleic Acids Res. 2025 Nov 13;53(21):gkaf1128. doi: 10.1093/nar/gkaf1128.

    Published on November 16, 2025

    Complex single-cell analyses now routinely integrate multiple datasets, followed by cell-type annotation and differential expression analysis. Current state-of-the-art integration methods often struggle with imbalanced cell Read more

    PUBLICATION

    Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis 

    Tiit Örd et al.

    Cardiovasc Res. 2025 Nov 7:cvaf210. doi: 10.1093/cvr/cvaf210. Online ahead of print.

    Published on November 9, 2025

    CONCLUSIONS: Our findings provide novel insights into macrophage-specific gene programs during atherosclerosis progression and identify a set of promising biomarkers that can serve as a Read more

    PUBLICATION

    Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma 

    Jie Bao et al.

    Biomed Pharmacother. 2025 Nov 6;193:118716. doi: 10.1016/j.biopha.2025.118716. Online ahead of print.

    Published on November 7, 2025

    Ovarian high-grade serous cancer (HGSC) is the most aggressive ovarian cancer subtype with limited treatment options. We identify the PDPK1 inhibitor BX-912 as a promising Read more

    PUBLICATION

    Nextpie: a web-based reporting tool and database for reproducible nextflow pipelines 

    Bishwa Ghimire et al.

    Bioinform Adv. 2025 Oct 10;5(1):vbaf252. doi: 10.1093/bioadv/vbaf252. eCollection 2025.

    Published on November 3, 2025

    MOTIVATION: High-throughput genomic data analysis consists of the inexorably intertwined inputs and outputs of a vast array of bioinformatic analysis tools. To guarantee streamlined and Read more

    PUBLICATION

    Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal-Amplifying Fluidic Biomimetic Hydrogel 

    Yingji Mao et al.

    Adv Sci (Weinh). 2025 Oct 15:e16398. doi: 10.1002/advs.202516398. Online ahead of print.

    Published on October 15, 2025

    Cranial stem cell niches (SCNs) are intrinsically scarce and hypoactive, and, exacerbated by chronic inflammation in diabetes, lead to niche failure and regenerative deficit after Read more

    PUBLICATION

    Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity 

    Prince Dadson et al.

    Obesity (Silver Spring). 2025 Oct 12. doi: 10.1002/oby.70041. Online ahead of print.

    Published on October 12, 2025

    CONCLUSIONS: These findings demonstrate significant molecular alterations in the VAT proteome associated with severe obesity, providing insights into the underlying mechanisms of metabolic disease. The Read more

    PUBLICATION

    Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study 

    Aaron Barron et al.

    Lancet Planet Health. 2025 Oct 9:101309. doi: 10.1016/j.lanplh.2025.101309. Online ahead of print.

    Published on October 12, 2025

    BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants associated with adverse health outcomes in humans. Although they are associated with autism spectrum Read more

    PUBLICATION

    LimROTS: A Hybrid Method Integrating Empirical Bayes and Reproducibility-Optimized Statistics for Robust Differential Expression Analysis 

    Ali Mostafa Anwara et al.

    Bioinformatics. 2025 Oct 11:btaf570. doi: 10.1093/bioinformatics/btaf570. Online ahead of print.

    Published on October 11, 2025

    MOTIVATION: Differential expression analysis plays a vital role in omics research enabling precise identification of features that associate with different phenotypes. This process is critical Read more

    PUBLICATION

    MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution 

    Ana Hernández de Sande et al.

    Genome Med. 2025 Oct 6;17(1):112. doi: 10.1186/s13073-025-01530-9.

    Published on October 7, 2025

    CONCLUSIONS: We demonstrate that miRNA gene transcriptional activity is widely impacted in immune cells by aging and during disease development and further identify the corresponding Read more

    PUBLICATION

    Functional characterization and directed evolution of Cicer arietinum glutathione transferases for enhanced hydroperoxidase activity and ligandin function 

    Anni Kontouri et al.

    Phytochemistry. 2025 Sep 27;242:114692. doi: 10.1016/j.phytochem.2025.114692. Online ahead of print.

    Published on September 29, 2025

    Tau class glutathione transferases (GSTUs) play essential roles in plant defense by facilitating the nucleophilic attack of glutathione (GSH) to a wide range of electrophilic Read more