Publications

Regulating macrophage glucose metabolism homeostasis via mitochondrial rheostats by short fiber-microsphere scaffolds for bone repair

Pengzhen Zhuang et al.

Bioact Mater. 2025 Mar 15;49:399-417. doi: 10.1016/j.bioactmat.2025.03.008. eCollection 2025 Jul.

The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as a pivotal rheostat for balancing glucose metabolism in immune cells, can effectively mitigate inflammation and initiate osteogenesis. Herein, an ion-activated mitochondrial rheostat fiber-microsphere polymerization system (FM@CeZnHA) was innovatively constructed. Physical-chemical and molecular biological...

Time, the final frontier

Gautier Follain et al.

Mol Oncol. 2025 Mar 24. doi: 10.1002/1878-0261.70025. Online ahead of print.

Cancer's notorious heterogeneity poses significant challenges, as each tumor comprises a unique ecosystem. While single-cell and spatial transcriptomics advancements have transformed our understanding of spatial diversity within tumors, the temporal dimension remains underexplored. Tumors are dynamic entities that continuously evolve and adapt, and relying solely on static snapshots obscures the intricate interplay between cancer cells and their microenvironment. Here, we advocate for...

Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use

Nataliia Petruk et al.

Sci Rep. 2025 Mar 19;15(1):9449. doi: 10.1038/s41598-025-92841-9.

CONCLUSIONS: High CD73 expression is associated with development of bone metastases. Zoledronate counteracts this effect. These results suggest that CD73 expression might serve as a biomarker for adjuvant zoledronic acid use.

Practical recommendations for developing software for life science applications

Joanna W Pylvänäinen et al.

J Cell Sci. 2025 Mar 1;138(5):jcs263711. doi: 10.1242/jcs.263711. Epub 2025 Mar 17.

Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scientists presents challenges to software adoption. In this Essay, we provide practical recommendations to guide bioimage analysts and developers in creating accessible and usable software for biological research. These recommendations are presented in three phases, covering software design, user involvement in...

Trajectories of microbiome-derived bile acids in early life – insights into the progression to islet autoimmunity

Santosh Lamichhane et al.

medRxiv [Preprint]. 2025 Feb 24:2025.02.18.25322275. doi: 10.1101/2025.02.18.25322275.

Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Here, we analyzed early-life MCBA patterns and their link to islet autoimmunity. We quantified 110 MCBAs in 303 stool samples collected longitudinally (3-36 months) from children who developed one or more islet autoantibodies and controls who remained autoantibody-negative. Stool MCBAs showed distinct...

Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing

Lu Fan et al.

Smart Med. 2025 Feb 26;4(1):e137. doi: 10.1002/smmd.137. eCollection 2025 Mar.

Wound healing has been a continuous critical focus in clinical practice, posing the ongoing challenges and burdens to patients. Current attempts tend to develop multi-drug loaded patches with spatial design. Herein, we present a multifunctional microneedle patch that integrates different drugs into separated regions for wound treatment. The microneedle patch is composed of silk fibroin-methacryloyl (SilMA) as the base, loaded with silver nanoparticles (AgNPs) and has gelatin methacryloyl (GelMA)...