Publications

    All Publications (240)

    Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring 
    Santosh Lamichhane et al. Environ Int. 2026 Jan 21;208:110080. doi: 10.1016/j.envint.2026.110080. Online ahead of print. Published January 25, 2026
    Emerging evidence suggests that environmental contaminants can influence both human metabolism and gut microbiota composition. However, the specific effects of prenatal exposure to persistent organic...
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    Preventing Proteomics Data Tombs Through Collective Responsibility and Community Engagement 
    Uladzislau Vadadokhau et al. Sci Data. 2026 Jan 22. doi: 10.1038/s41597-026-06614-8. Online ahead of print. Published January 22, 2026
    Public proteomics repositories now host vast amounts of mass spectrometry data, yet much of it remains difficult to reuse, risking "data tombs" that are open...
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    Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells 
    Valentin Gensbittel et al. Nat Mater. 2026 Jan 19. doi: 10.1038/s41563-025-02462-w. Online ahead of print. Published January 19, 2026
    Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs)...
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    Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence 
    Hani Vu et al. JHEP Rep. 2025 Nov 4;8(2):101657. doi: 10.1016/j.jhepr.2025.101657. eCollection 2026 Feb. Published January 16, 2026
    CONCLUSIONS: Taken together, our valuable discovery dataset highlights the complex crosstalk between metabolic perturbations and inflammation underpinning fibrosis progression in MASLD.
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    The inflammatory path toward type 1 diabetes begins during pregnancy 
    Angelica P Ahrens et al. Nat Commun. 2026 Jan 7. doi: 10.1038/s41467-025-67712-6. Online ahead of print. Published January 7, 2026
    Type 1 diabetes (T1D) is increasing globally, yet the earliest biological determinants remain poorly defined, particularly in general population studies. We studied the Swedish population-based...
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    Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers 
    Gautier Follain et al. EMBO J. 2026 Jan 6. doi: 10.1038/s44318-025-00678-9. Online ahead of print. Published January 6, 2026
    The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we...
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    Bone marrow failure, somatic rescue by p53 inactivation, and enhanced leukemogenesis in germ line ERCC6L2 disease 
    Roman R Schimmer et al. Blood. 2026 Apr 9;147(15):1663-1679. doi: 10.1182/blood.2025030230. Published January 6, 2026
    Recessively inherited loss-of-function mutations in excision repair cross-complementing 6-like 2 (ERCC6L2) cause a bone marrow failure (BMF) syndrome characterized by moderate cytopenias, frequent somatic TP53...
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    Single-cell RNA-seq analysis of longitudinal CD4+ T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes 
    Rahul Biradar et al. Genome Med. 2025 Dec 29;17(1):154. doi: 10.1186/s13073-025-01574-x. Published December 30, 2025
    CONCLUSIONS: Our findings reveal early, cell-type-specific changes in transcription and gene regulatory networks in CD4⁺ T cells associated with type 1 diabetes progression, highlighting key...
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    Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies 
    Veera K Ojala et al. Mol Oncol. 2025 Dec 23. doi: 10.1002/1878-0261.70189. Online ahead of print. Published December 24, 2025
    Receptor tyrosine kinase ERBB4 (HER4) is frequently mutated in human cancer, and ERBB4 mutations have been identified in patients relapsing on targeted therapy. Here, we...
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    PhotoFiTT: a quantitative framework for assessing phototoxicity in live-cell microscopy experiments 
    Mario Del Rosario et al. Nat Commun. 2025 Dec 13. doi: 10.1038/s41467-025-66209-6. Online ahead of print. Published December 13, 2025
    Phototoxicity in live-cell fluorescence microscopy can compromise experimental outcomes, yet quantitative methods to assess its impact remain limited. Here, we present PhotoFiTT (Phototoxicity Fitness Time...
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    A resource to empirically establish drug exposure records directly from untargeted metabolomics data 
    Haoqi Nina Zhao et al. Nat Commun. 2025 Dec 9;16(1):10600. doi: 10.1038/s41467-025-65993-5. Published December 9, 2025
    Despite extensive efforts, extracting medication exposure information from clinical records remains challenging. To complement this approach, here we show the Global Natural Product Social Molecular...
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    Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity 
    Santosh Lamichhane et al. Nat Commun. 2025 Dec 3. doi: 10.1038/s41467-025-66619-6. Online ahead of print. Published December 3, 2025
    Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health...
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