Publications

    All Publications (242)

    Limitations of de novo peptide sequencing in resolving sequence ambiguity 
    Sam van Puyenbroeck et al. Nat Methods. 2026 Nov 3. doi: 10.1038/s41592-026-03301-9. Online ahead of print. Published November 3, 2026
    De novo peptide sequencing enables peptide identification from fragmentation spectra without relying on sequence databases. However, incomplete spectra create ambiguity, making unambiguous identification challenging. Recent...
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    Nanoparticle delivery systems for gene therapy of degenerative musculoskeletal diseases 
    Xiaofei Chen et al. J Orthop Translat. 2026 Oct 25;61:101241. doi: 10.1016/j.jot.2026.101241. eCollection 2026 Nov. Published October 31, 2026
    Degenerative musculoskeletal diseases (DMDs) are a group of chronic conditions characterized by the progressive deterioration of tissue structure and function, primarily affecting the articular cartilage,...
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    Comparative Pharmacological Effects of Tetracycline Derivatives on Osteoclast- and Osteoblast-Related Phenotypes and Skeletal Accumulation 
    Saeka Shimochi et al. Pharmaceuticals (Basel). 2026 Oct 10;19(10):1610. doi: 10.3390/ph19101610. Published October 27, 2026
    Background/Objectives: Tetracycline (TC) derivatives possess biological activities beyond their antimicrobial effects and exhibit affinity for mineralized tissues. However, direct comparisons of clinically established TC derivatives...
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    Maternal transmission and limited virulent phage replication shape early infant gut virome maturation 
    Kim Kreuze et al. Res Sq [Preprint]. 2026 Oct 5:rs.3.rs-11232673. doi: 10.21203/rs.3.rs-11232673/v1. Published October 25, 2026
    Early-life gut microbiome dynamics are increasingly recognized as important determinants of microbiome maturation, yet the ecological dynamics of its associated bacteriophages remain poorly resolved. Here,...
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    Adipose tissue transcriptome before and after surgery: effects on genes driving lipid metabolism, inflammation, and RNA processing 
    Prince Dadson et al. Int J Obes (Lond). 2026 Oct 16. doi: 10.1038/s41366-026-02243-8. Online ahead of print. Published October 16, 2026
    CONCLUSIONS: These findings demonstrate SAT and VAT remodeling in obesity and show that MBS partially reverses transcriptional changes in SAT, providing mechanistic insight into its...
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    Ultra-stable Zn/Fe bimetallic DNA nanonetworks enable glucose-deprivation-sensitized ferroptosis for gastric cancer therapy 
    Jiaqi Yan et al. Biomaterials. 2026 Sep 30;338(Pt A):124669. doi: 10.1016/j.biomaterials.2026.124669. Online ahead of print. Published October 7, 2026
    Metal-coordinated DNA nanostructures have emerged as promising drug delivery platforms owing to their rapid synthesis and high loading capacity. However, current systems degrade within two...
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    From gut to lung: Microbiota-derived metabolites reshaping the tumor immune microenvironment 
    Prabesh Baniya et al. EXCLI J. 2026 Aug 20;25:1383-1387. doi: 10.17179/excli2026-9646. eCollection 2026. Published October 7, 2026
    Lung cancer remains the leading cause of cancer-related mortality worldwide, and non- small cell lung cancer (NSCLC), which comprises the vast majority of lung cancer...
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    Fast and slow gene expression changes in blood following acute social stress 
    Hampus Grönvall et al. Brain Behav Immun Health. 2026 Sep 17;57:101365. doi: 10.1016/j.bbih.2026.101365. eCollection 2026 Nov. Published October 2, 2026
    Social stress is a risk factor for psychiatric disorders and also influences immune function. While it is known that acute social stress impacts the number...
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    A candidate CD4⁺ T-cell gene expression panel for multiple sclerosis highlights MgADP-associated genes 
    Haifeng Xu et al. Mult Scler Relat Disord. 2026 Sep 24;115:107944. doi: 10.1016/j.msard.2026.107944. Online ahead of print. Published September 29, 2026
    Multiple sclerosis (MS) is an autoimmune disease characterized by immune cell dysregulation. HLA class II alleles drive the disease risk, thereby highlighting CD4^(+) T cells...
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    Asymmetric Structure-Driven Functional Synergy: A Multistimuli-Activated Janus Nanomotor for Self-Amplifying NO Cascade Therapy 
    Chengcheng Li et al. Adv Sci (Weinh). 2026 Sep 27:e77848. doi: 10.1002/advs.77848. Online ahead of print. Published September 27, 2026
    Nitric oxide (NO)-based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a...
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    Metabolic modeling with reverse mapping links host perturbations to Mycobacterium tuberculosis 
    Jayendrajyoti Kundu et al. iScience. 2026 Sep 17;29(10):117477. doi: 10.1016/j.isci.2026.117477. eCollection 2026 Oct 16. Published September 25, 2026
    Understanding host-pathogen interactions during Mycobacterium tuberculosis (Mtb) infection has largely relied on identifying bacterial genes essential for intracellular survival. However, conventional reverse genetics approaches often...
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    Long-term recovery and microbiota-gut-brain axis disruption after traumatic brain injury (OVERCOME-TBI): protocol for a prospective, observational clinical study 
    Matti Artosalo et al. BMJ Open. 2026 Sep 23;16(9):e120552. doi: 10.1136/bmjopen-2026-120552. Published September 23, 2026
    INTRODUCTION: Traumatic brain injury (TBI) is a major cause of long-term disability worldwide, but the pathophysiological mechanisms underlying its chronic sequelae remain incompletely understood. In...
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