The inflammatory path toward type 1 diabetes begins during pregnancy 

Angelica P Ahrens et al.

Nat Commun. 2026 Jan 7. doi: 10.1038/s41467-025-67712-6. Online ahead of print.

Published on January 7, 2026

Type 1 diabetes (T1D) is increasing globally, yet the earliest biological determinants remain poorly defined, particularly in general population studies. We studied the Swedish population-based Read more

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers 

Gautier Follain et al.

EMBO J. 2026 Jan 6. doi: 10.1038/s44318-025-00678-9. Online ahead of print.

Published on January 6, 2026

The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we Read more

Single-cell RNA-seq analysis of longitudinal CD4+ T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes 

Rahul Biradar et al.

Genome Med. 2025 Dec 29;17(1):154. doi: 10.1186/s13073-025-01574-x.

Published on December 30, 2025

CONCLUSIONS: Our findings reveal early, cell-type-specific changes in transcription and gene regulatory networks in CD4⁺ T cells associated with type 1 diabetes progression, highlighting key Read more

Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies 

Veera K Ojala et al.

Mol Oncol. 2025 Dec 23. doi: 10.1002/1878-0261.70189. Online ahead of print.

Published on December 24, 2025

Receptor tyrosine kinase ERBB4 (HER4) is frequently mutated in human cancer, and ERBB4 mutations have been identified in patients relapsing on targeted therapy. Here, we Read more

PhotoFiTT: a quantitative framework for assessing phototoxicity in live-cell microscopy experiments 

Mario Del Rosario et al.

Nat Commun. 2025 Dec 13. doi: 10.1038/s41467-025-66209-6. Online ahead of print.

Published on December 13, 2025

Phototoxicity in live-cell fluorescence microscopy can compromise experimental outcomes, yet quantitative methods to assess its impact remain limited. Here, we present PhotoFiTT (Phototoxicity Fitness Time Read more

A resource to empirically establish drug exposure records directly from untargeted metabolomics data 

Haoqi Nina Zhao et al.

Nat Commun. 2025 Dec 9;16(1):10600. doi: 10.1038/s41467-025-65993-5.

Published on December 9, 2025

Despite extensive efforts, extracting medication exposure information from clinical records remains challenging. To complement this approach, here we show the Global Natural Product Social Molecular Read more

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity 

Santosh Lamichhane et al.

Nat Commun. 2025 Dec 3. doi: 10.1038/s41467-025-66619-6. Online ahead of print.

Published on December 3, 2025

Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health Read more

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway 

Martina Lerche et al.

J Cell Biol. 2026 Feb 2;225(2):e202508155. doi: 10.1083/jcb.202508155. Epub 2025 Dec 2.

Published on December 2, 2025

Constitutive integrin endocytosis and recycling control cell movement and morphology. In contrast, the role of newly synthesized integrins delivered via the biosynthetic pathway has been Read more

Mitochondria-Targeted Nanomotor: H2S-Driven Cascade Therapy for Hepatocellular Carcinoma 

Chengcheng Li et al.

Adv Mater. 2025 Dec 1:e13757. doi: 10.1002/adma.202513757. Online ahead of print.

Published on December 2, 2025

Despite advances in combination therapies for cancer treatment, most strategies rely on modular-additive designs that lack dynamic molecular cues to achieve intrinsic synergy. Herein, a Read more

JNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation 

Ye Hong et al.

Neurobiol Dis. 2025 Nov 29;218:107207. doi: 10.1016/j.nbd.2025.107207. Online ahead of print.

Published on November 30, 2025

c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo Read more

Disrupting Complement-Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation 

Yu Zhang et al.

Adv Mater. 2025 Nov 28:e18378. doi: 10.1002/adma.202518378. Online ahead of print.

Published on November 28, 2025

The positive feedback circuit between the complement system and inflammatory immune responses maps the malignant progression of chronic joint inflammation. Prolonged dysregulation of the immune Read more

Vimentin in the tumor microenvironment: orchestrating invasion, immunity, and metabolism 

Sepideh Parvanian et al.

Eur J Cell Biol. 2025 Nov 21;104(4):151523. doi: 10.1016/j.ejcb.2025.151523. Online ahead of print.

Published on November 27, 2025

Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of Read more