New funding for target discovery related to SynGAP1-associated non-syndromic intellectual disability
We are excited to be starting a new project on SynGAP thanks to support from Leon & friends e.V.
SynGAP is a protein that reduces the activity of Ras-GTPases, which are important in regulating the ERK group of MAP kinases and synaptic connectivity. Mutations in the SynGAP1-gene can cause a non-syndromic intellectual disability (NSID) disorder that often includes epilepsy. Our project aims to make use of our recently developed high-throughout physiology pipeline to identify RasGEF proteins, the RasGTPase activators, that counteract the neuronal signalling affected by reduced SynGAP levels. These RasGEFs could potentially be druggable targets relevant for drug discovery approaches to treat SynGAP-associated NSID.
Recent Posts
- University of Turku celebrates Professor Shimon Sakaguchi’s Nobel prize Professor Shimon Sakaguchi, winner of the 2025 Nobel Prize in Medicine, is a visiting professor Read moreOctober 7, 2025
- Heidi Isokääntä Successfully Defends Dissertation on Gut Microbiome Development Heidi Isokääntä Successfully Defends Dissertation on Gut Microbiome Deveopment Turku, 26 September 2025 – Bioanalyst Read moreSeptember 29, 2025
- University of Jyväskylä to Award Honorary Doctorate to Johanna Ivaska The University of Jyväskylä will award 11 new honorary doctorates in May 2026. One of Read moreSeptember 26, 2025
- Turku Metabolomics Core Enhances MALDI Imaging with New Sprayer The Turku Metabolomics Core, part of the Turku Bioscience Centre, has acquired a SunCollect MALDI Read moreSeptember 19, 2025
- Christel Sourander Successfully Defends Her Thesis Congratulations! Christel Sourander successfully defended her thesis: “Identifying the effect of JNK on neural activity Read moreSeptember 9, 2025
- Researchers at Åbo Akademi University Discover a New Molecular Switch Regulating Breast Cancer Progression A research group led by our our affiliated group leader Professor Lea Sistonen at Åbo Read moreSeptember 4, 2025