Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells. Sci Rep. 2016 Feb 25;6:22190. IF: 5.578 [NGS]

    Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Söderström M, Emani MR, Stubb A, Närvä E,Ghimire B,Laiho A, Järveläinen H, Lahesmaa R, Lähdesmäki H, Hawkins RD,Lund RJ

    Scientific Reports (2016)

    Published on December 2, 2025

    DOI: https://doi.org/10.1038/srep22190

    Core: Finnish Functional Genomics Centre

    Abstract

    AbstractEpigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.
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