All Core Facilities Publications

    Publications 2026 (15)

    Genes associated with immune response are upregulated in clinically healthy skin of patients with gliptin-associated bullous pemphigoid
    Nina Kokkonen, Outi Varpuluoma, Jussi Tuusa, Katri Pylkäs, Laura Huilaja, Kaisa TasanenJournal of Investigative Dermatology (2026)
    Core:Finnish Functional Genomics Centre
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    Emerging Microbial Lipid Shifts in a Multistage Simulated Gut Inoculated with Human Fecal Microbiota
    Ifrat Tamanna, Katja Salonen, Helena Mannochio-Russo, Matilda Kråkström, Paulo Wender P. Gomes, Vincent Charron-Lamoureux, Ipsita Mohanty, Sofia D. Forssten, Arthur C. Ouwehand, Tuulia Hyötyläinen, Alex M. Dickens, Pieter C. Dorrestein, Matej Orešič, Santosh LamichhaneJournal of Proteome Research (2026)
    Abstract Food residues that bypass human digestion are further digested by gut microbes, leading to the production of diverse metabolites,...
    Core:Metabolomics
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    Improving genotyped functional screening: A versatile closed-tube PCR for Illumina library generation reduces background sequences in multiplexed sequencing
    Sami Oksanen, Tuomas Huovinen, Urpo LamminmäkiSLAS Technology (2026)
    Core:Finnish Functional Genomics Centre
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    Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation
    James T. Grist, Ilia Evstafev, Dominika Olesova, Signe E. Nynäs, Matej Orešič, Alex M. Dickens, Damian J. Tyler, Yvonne CouchJournal of Neuroinflammation (2026)
    Abstract Given the prevalence of metabolic perturbations in a variety of neurological and neurodegenerative diseases, understanding and monitoring brain metabolism...
    Core:Metabolomics
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    <i>Staphylococcus aureus</i> Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
    Maria Gluud, Emil M. Pallesen, Ziao Zeng, Martin R. J. Namini, Chella Krishna Vadivel, Lise Mette Rahbek Gjerdrum, Lang Yan, Sana Ahmad, Lise M. Lindahl, Michael Bzorek, Maria R. Kamstrup, Saptaswa Dey, Sisse Rye Ostrowski, Erik Sørensen, Pia Rantakari, Charlotte Menne Bonefeld, Carsten Geisler, Anders Woetmann, Riitta Lahesmaa, Lars Iversen, Peter Wolf, Thomas Litman, Terkild B. Buus, Niels ØdumAllergy (2026)
    ABSTRACT Background Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T‐cell lymphoma...
    Core:Cytometry Core
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    Isomeric cues direct macrocycle selection from complex chemical systems for selective separation and recycling
    Xin Wang, Jinghui Yang, Emil Rosqvist, Yonglei Lyu, Anastassios C. Papageorgiou, Jouko Peltonen, Ermei Mäkilä, Fangyi Cheng, Jianwei LiCell Reports Physical Science (2026)
    Core:Protein Structure and Chemistry
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    Dynamic landscape of transcription initiation by yeast RNA polymerase I
    Olena Parilova, Piia Bartos, Anssi M MalinenNucleic Acids Research (2026)
    Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity...
    Core:Protein Structure and Chemistry
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    Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes
    Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia HyötyläinenEnvironment International (2026)
    Core:Metabolomics
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    Functional characterization and directed evolution of Cicer arietinum glutathione transferases for enhanced hydroperoxidase activity and ligandin function
    Anni Kontouri, Nikolaos Georgakis, Anastassios C. Papageorgiou, Nikolaos Ε. LabrouPhytochemistry (2026)
    Core:Protein Structure and Chemistry
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    Synthesis and Characterization of Glyco‐Decorated Silsesquioxane‐Metallosalen Complexes
    Hanni Haapsaari, Tytti Taipale, Petri Tähtinen, Anssi Peuronen, Pasi VirtaChemistrySelect (2026)
    ABSTRACT Cube‐octameric silsesquioxanes (COSS) present interesting opportunities in several applications due to their rigid inorganic and biocompatible silicate core combined...
    Core:Protein Structure and Chemistry
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    Rab24 protein levels show dynamic changes in mouse tissues and human cancers
    H. G. Mauricio Ramm, Farhad Ahmed, Sadaf Fazeli, Matthieu Bourgery, Martin Alexander Lopez, Lav Tripathi, Ilmo Leivo, Pernilla Syrjä, Eeva-Liisa EskelinenCell and Tissue Research (2026)
    Abstract Rab24 is an unusual member of the Rab family of small GTPases, implicated in autophagy, endocytosis and cell division....
    Core:Finnish Functional Genomics Centre
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    Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis
    Heba Nabil, Mahmoud-Sobhy Elkhwanky, Mohamed Hassanen, Einari A. Niskanen, Raghavendra Mysore, Jorma J. Palvimo, Outi Kummu, Jukka HakkolaArchives of Toxicology (2026)
    Core:Finnish Functional Genomics Centre
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    Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
    Gautier Follain, Sujan Ghimire, Joanna W Pylvänäinen, Monika Vaitkevičiūtė, Iván Hidalgo-Cenalmor, Diana Wurzinger, Camilo Guzmán, James R W Conway, Michal Dibus, Jouni Härkönen, Sanna Oikari, Kirsi Rilla, Marko Salmi, Johanna Ivaska, Guillaume JacquemetThe EMBO Journal (2026)
    Abstract The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these...
    Core:Advanced Imaging Core
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    Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort
    Katja Pahkala, Suvi Rovio, Noora Kartiosuo, Kari Auranen, Matthieu Bourgery, Marko Elovainio, Mikael Fogelholm, Johanna Haapala, Mirja Hirvensalo, Nina Hutri, Eero Jokinen, Antti Jula, Markus Juonala, Jari Kaikkonen, Hannu Kiviranta, Juhani S Koskinen, Noora Kotaja, Mika Kähönen, Tomi P Laitinen, Terho Lehtimäki, Irina Lisinen, Britt-Marie Loo, Leo-Pekka Lyytikäinen, Costan G Magnussen, Pashupati P Mishra, Juha Mykkänen, Juho-Antti Mäkelä, Satu Männistö, Jaakko Nevalainen, Laura Pulkki-Råback, Emma Raitoharju, Panu Rantakokko, Tapani Rönnemaa, Sini Stenbacka, Leena Taittonen, Tuija H Tammelin, Jorma Toppari, Päivi Tossavainen, Jorma Viikari, Olli RaitakariInternational Journal of Epidemiology (2026)
    Core:Finnish Functional Genomics Centre
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    Genetically Induced Mouse Model for Colon-specific Epithelial Cell Tumorigenesis Driven by Loss of K8 and Apc
    Mina Tayyab, Mira M.E. Minkkinen, Carl-Gustaf A. Stenvall, Lauri Polari, Victor Nielsen, Yatrik M. Shah, Diana M. ToivolaCellular and Molecular Gastroenterology and Hepatology (2026)
    Core:Advanced Imaging Core
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