Genome Editing Master

    10.1016/j.imlet.2023.09.00

    Published on December 3, 2025

    Core: Genome Editing Core
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    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
    O. Kauko et al. • 2025 • Science Advances
    Mutations in numerous genes contribute to human cancer, with different oncogenic lesions prevalent in different cancer types. However, the malignant... Read more
    Core:ProteomicsProteomics Highlight
    Genes associated with immune response are upregulated in clinically healthy skin of patients with gliptin-associated bullous pemphigoid
    N. Kokkonen et al. • 2026 • Journal of Investigative Dermatology
    Core:Finnish Functional Genomics Centre
    Genotyped functional screening of soluble Fab clones enables in-depth analysis of mutation effects
    S. Oksanen et al. • 2023 • Scientific Reports
    AbstractMonoclonal antibodies (mAbs) and their fragments are widely used in therapeutics, diagnostics and basic research. Although display methods such as... Read more
    Core:Finnish Functional Genomics Centre
    Improving genotyped functional screening: A versatile closed-tube PCR for Illumina library generation reduces background sequences in multiplexed sequencing
    S. Oksanen et al. • 2026 • SLAS Technology
    Core:Finnish Functional Genomics Centre
    Dynamic landscape of transcription initiation by yeast RNA polymerase I
    O. Parilova et al. • 2026 • Nucleic Acids Research
    Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity... Read more
    Core:Protein Structure and Chemistry

    More User Publications

    User Publication
    December 3, 2025
    Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
    Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck Nature Communications (2023)
    AbstractThe protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer...
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