Genome Editing Core Publications

    Publications 2023 (8)

    <scp>PP2A</scp> ‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells
    Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina von Schantz‐Fant, Michael Ohlmeyer, Krister Wennerberg, Otto Kauko, Raphael Koch, Tero Aittokallio, Mikko Taipale, Jukka WestermarckMolecular Oncology (2023)
    Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase...
    Core:Genome Editing Core
    Read abstract
    <scp>PP2A</scp> methylesterase <scp>PME</scp> ‐1 suppresses anoikis and is associated with therapy relapse of <scp> <i>PTEN</i> </scp> ‐deficient prostate cancers
    Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song‐Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka WestermarckMolecular Oncology (2023)
    While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge. Resistance to...
    Core:Genome Editing Core
    Read abstract
    Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling
    James R. W. Conway, Aleksi Isomursu, Gautier Follain, Ville Härmä, Eva Jou-Ollé, Nicolas Pasquier, Eetu P. O. Välimäki, Juha K. Rantala, Johanna IvaskaProceedings of the National Academy of Sciences (2023)
    Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to...
    Core:Genome Editing Core
    Read abstract
    HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function
    Syed Bilal Ahmad Andrabi, Kedar Batkulwar, Santosh D. Bhosale, Robert Moulder, Meraj Hasan Khan, Tanja Buchacher, Mohd Moin Khan, Ilona Arnkil, Omid Rasool, Alexander Marson, Ubaid Ullah Kalim, Riitta LahesmaaImmunology Letters (2023)
    Core:Genome Editing Core
    Read abstract
    IGFBP2 secretion by mammary adipocytes limits breast cancer invasion
    James R. W. Conway, Defne D. Dinç, Gautier Follain, Oona Paavolainen, Jasmin Kaivola, Pia Boström, Pauliina Hartiala, Emilia Peuhu, Johanna IvaskaScience Advances (2023)
    The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a...
    Core:Genome Editing Core
    Read abstract
    Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394
    Elina Siljamäki, Pilvi Riihilä, Ujjwal Suwal, Liisa Nissinen, Pekka Rappu, Markku Kallajoki, Veli-Matti Kähäri, Jyrki HeinoOncogene (2023)
    AbstractCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of patients with metastatic cSCC is...
    Core:Genome Editing Core
    Read abstract
    Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress
    Laura Virtanen, Emilia Holm, Mona Halme, Gun West, Fanny Lindholm, Josef Gullmets, Juho Irjala, Tiina Heliö, Artur Padzik, Annika Meinander, John E. Eriksson, Pekka TaimenJournal of Cell Science (2023)
    ABSTRACT The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by the...
    Core:Genome Editing Core
    Read abstract
    Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
    Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka WestermarckNature Communications (2023)
    AbstractThe protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer...
    Core:Genome Editing Core
    Read abstract