SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

    Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska

    Nature Communications (2024)

    Published on December 3, 2025

    DOI: https://doi.org/10.1038/s41467-024-52326-1

    Core: Advanced Imaging Core
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