Cellular recognition and macropinocytosis-like internalization of nanoparticles targeted to integrin α2β1

    P. Kankaanpää, S. Tiitta, L. Bergman, A.-B. Puranen, E. von Haartman, M. Lindén, J. Heino

    Nanoscale (2015)

    Published on December 4, 2025

    DOI: https://doi.org/10.1039/c5nr06218g

    Core: Advanced Imaging Core

    Abstract

    Silica-based nanoparticles are targeted to α2β1 integrin cell surface receptor. Analysis with BioImageXD reveals them to be endocytosed into human cellsviamacropinocytosis, through GM1, Caveolin-1 and Rab7 positive pathways.
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