Cellular recognition and macropinocytosis-like internalization of nanoparticles targeted to integrin α2β1

    Authors: P. Kankaanpää, S. Tiitta, L. Bergman, A.-B. Puranen, E. von Haartman, M. Lindén, J. Heino

    Journal: Nanoscale

    Year: 2015

    DOI: https://doi.org/10.1039/c5nr06218g

    Abstract

    Silica-based nanoparticles are targeted to α2β1 integrin cell surface receptor. Analysis with BioImageXD reveals them to be endocytosed into human cellsviamacropinocytosis, through GM1, Caveolin-1 and Rab7 positive pathways.