The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research

    Anh Hoang Nguyen, Victor Castro-Alves, Emilia Holmström Flores, João Marcos G. Barbosa, Matilda Kråkström, Päivikki Reinivuori, Otto Kauko, Alex Dickens, Matej Orešič, Tuulia Hyötyläinen

    Analytical Chemistry (2025)

    Published on November 12, 2026

    DOI: https://doi.org/10.1021/acs.analchem.5c05322

    Core: Metabolomics
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    Emerging Microbial Lipid Shifts in a Multistage Simulated Gut Inoculated with Human Fecal Microbiota
    I. Tamanna et al. • 2026 • Journal of Proteome Research
    Abstract Food residues that bypass human digestion are further digested by gut microbes, leading to the production of diverse metabolites,...
    Core:Metabolomics
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    Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes
    A. Alijagic et al. • 2026 • Environment International
    Core:Metabolomics
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    Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation
    J. Grist et al. • 2026 • Journal of Neuroinflammation
    Abstract Given the prevalence of metabolic perturbations in a variety of neurological and neurodegenerative diseases, understanding and monitoring brain metabolism...
    Core:Metabolomics
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    Genes associated with immune response are upregulated in clinically healthy skin of patients with gliptin-associated bullous pemphigoid
    N. Kokkonen et al. • 2026 • Journal of Investigative Dermatology
    Core:Finnish Functional Genomics Centre
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    Improving genotyped functional screening: A versatile closed-tube PCR for Illumina library generation reduces background sequences in multiplexed sequencing
    S. Oksanen et al. • 2026 • SLAS Technology
    Core:Finnish Functional Genomics Centre
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    November 12, 2026
    SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells
    Emma Valima, Vera Varis, Kseniia Bureiko, Joanna K. Lempiäinen, Anna-Mari Schroderus, Laura Oksa, Olli Lohi, Tuure Kinnunen, Markku Varjosalo, Einari A. Niskanen, Ville Paakinaho, Jorma J. Palvimo Oncogene (2025)
    Abstract Glucocorticoids are a mainstay in the treatment of B-cell acute lymphoblastic leukemia (B-ALL). The glucocorticoid receptor (GR), a ligand-activated...
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