Imaging mass cytometry (IMC)

    Imaging mass cytometry (IMC) is an advanced technology that combines mass cytometry with high-resolution imaging to provide spatially resolved, multiparametric analysis of tissue sections and cellular samples. Using metal-tagged antibodies, IMC enables the simultaneous detection of numerous biomarkers without spectral overlap, preserving tissue architecture while offering deep insights into cellular interactions and microenvironments.

    (photograph by H. Jokela)
    image by H. Jokela

    Hyperion

    This is the imaging unit, which combined with the mass cytometer Helios forms the platform for imaging mass cytometry.

    The platform can simultaneously detect up to 37 protein markers in biological samples, including FFPE sections, frozen tissue sections, or cells deposited onto glass slides (liquid biopsies). This allows researchers to investigate cellular subpopulations in various tissue microenvironments. The system allows for cellular profiling in spatial proximity, enabling subpopulation profiling and exploration of relationships of neighboring cells within the context of the tissue structure.

    Proximity, enabling subpopulation profiling and exploration of relationships of neighboring cells within the context of the tissue structure.

    Human Breast cancer (H. Jokela)
    human breast cancer, image by (H. Jokela)