A new method for producing blood stem cells may in the future replace voluntary bone marrow donors as a source of stem cell transplants. Four European research groups will work…
Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors
CONCLUSION: This collaborative exercise emphasized the broad chemical survey possible with multi-technique approaches. Community engagement is essential for the evaluation and characterization of common materials designed to facilitate comparability and…
xCT as a Predictor for Survival in a Population-Based Cohort of Head and Neck Squamous Cell Carcinoma
CONCLUSIONS: High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value in OPSCC treatment stratification.
Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy
From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While superresolution microscopy can visualise such patterns, manual detection…
Imaging cell architecture and dynamics
No abstract…
Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy
M2-type macrophages (M2Φ) play a pro-tumorigenic role and are closely associated with tumor development, where metabolic dysregulation exacerbates the immunosuppressive tumor microenvironment and fosters tumor growth. Mitochondria serve as the…
Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer
Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly understood. Here, we report a…
Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging
Routine histochemical techniques are capable of producing vast amount of information from diverse sample types, but these techniques are limited in their ability to generate 3D information. Autofluorescence imaging can…
MSc Thesis Project Expo 2024: Come and find MSc students to join your lab!
Are you looking for MSc students to join your group? Come to the MSc Thesis Project Expo on 4 December 2024 and pick the best students! MSc Thesis Project Expo…
Empirically establishing drug exposure records directly from untargeted metabolomics data
Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based GNPS Drug Library. This resource…