Per- and polyfluoroalkyl substances (PFAS) are highly persistent environmental pollutants that bioaccumulate in living organisms and are increasingly implicated in metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondria, as central regulators…
Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up
Childhood obesity is rising globally. Yet, few studies have examined the microbiome and proteome in early childhood in relation to this outcome, and most are cross-sectional by design. Early-life factors…
Clarifying the scope and capabilities of ROTS in differential expression analysis
SUMMARY: Recently, Anwar et al. introduced a method combining the ROTS reproducibility optimisation procedure with empirical Bayes variance estimation from limma. Here, we clarify several methodological aspects to support accurate…
Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep
How the brain compensates for sleep deprivation (SD) by generating recovery sleep (RS) is not understood. Using Ca²⁺ photometry, we identified a WAKE/rapid eye movement sleep (REMS)-active somatostatin/parvalbumin GABAergic population…
Doctoral researcher position at Westermarck laboratory
The Westermarck Laboratory at Turku Bioscience Centre is accepting applications for a doctoral researcher (PhD) position. The project investigates the role of NOCIVA, a splicing variant of the…
Joint modeling of longitudinal and time-to-event data for dynamic disease risk prediction using proteomics
Biomedical studies increasingly incorporate longitudinal data, enabling us to track individual disease processes over time at the molecular level, and to discover associations of the molecular profiles with the outcome…
Association between infant and toddler gut microbiota composition and later executive functioning
CONCLUSIONS: Alpha diversity in infancy was negatively associated with preschool EF. Additionally, EFs differed between microbial groups based on dominant genera. Bacterial genera abundances were related to some EFs, but…
Novel CRISPR-Cas9 BAP1 knockout pre-clinical tumor model recapitulates human melanoma tumorigenesis and immune evolution
BAP1-deficient melanocytic tumors exhibit strong immunosuppressive features and poor prognosis. Currently, no immune-competent preclinical models exist to study their tumor-immune interactions or test new immunotherapies. This limitation hinders progress in…
Gene-programmed micro-nano metabolic engine drives coupled osteogenic-angiogenic regeneration
Effective bone healing is accompanied by coupled osteogenic-angiogenic regeneration, a process that critically depends on metabolic communication between bone marrow mesenchymal stem cells (BMSCs) and endothelial cells through an endogenous…
REACTOR: REgulon Activity analysis and Comparison Tool for single-cell transcriptOmics Research
SUMMARY: We introduce REACTOR, a computational tool designed to detect differential activity of transcriptional regulators and their target genes (regulons) in single-cell RNA-sequencing data. It expands the currently available framework…