Biotin is a vital cofactor in cellular carboxylation reactions and avidins are biotin-binding proteins that are produced by bacteria and fungi but also by egg-laying vertebrates, including avian species and…
Nutrient intake, gut inflammation markers, and intestinal permeability in infants aged 6-12 months
CONCLUSION: While breastfeeding remains a major determinant of gut maturation, consumption of complementary foods higher in intercorrelated nutrients including dietary fibre and potassium is associated with lower gut inflammation markers…
Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptides
While recent studies have revealed much about the pathogenesis of type 1 diabetes (T1D), the self-antigens and immune receptors that drive cellular autoimmunity have not been precisely determined. In this…
CRISPR activation of DLX5 drives neural progenitors to the GnRH cell fate
Gonadotropin-releasing hormone (GnRH) neurons regulate the hypothalamic-pituitary-gonadal (HPG) axis and are required for puberty onset and reproductive competence. However, the transcriptional regulators governing GnRH neuron specification and migration remain poorly…
Maternal Intake of Vitamins A, C, D, and E During Pregnancy and Risk of Type 1 Diabetes in the Child: The Norwegian Mother, Father, and Child Cohort Study
CONCLUSIONS: This prospective cohort study does not support the hypothesis that higher maternal intake of vitamins A, C, D, and E during pregnancy would decrease risk of type 1 diabetes…
Persistence of memory: lifespan dynamics of the human antiviral antibody reactome
The human antiviral antibody reactome provides a cumulative molecular record of immune exposures. Using high-resolution VirScan profiling, we compared epitope-level antibody responses across early childhood and adulthood. Infants are born…
A biocompatible copper based therapeutic nanoplatform for CD44 specific tumor targeted therapy and potent immune reprogramming
Despite advances in oncology, the dual challenge of achieving precise tumor-targeted therapy while simultaneously activating antitumor immunity remains a major clinical barrier. In this study, we engineered a biocompatible copper-based…
Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights
Tumor border configuration influences colorectal cancer (CRC) prognosis, yet its molecular determinants remain unclear and existing assessment criteria have faced challenges with reproducibility. We introduce the Tumor Invasive Border Index…
Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling
The blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic understanding of how these receptors…
Prognostic role of histological depth of invasion in T1-2 oropharyngeal squamous cell carcinoma
CONCLUSION: DOI was not a prognostic factor in p16-positive T1-2 OPSCC. Nevertheless, DOI may hold prognostic relevance for p16-negative disease. The patterns of local invasion and locoregional spread in OPSCC…