Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such…
Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence
CONCLUSIONS: Taken together, our valuable discovery dataset highlights the complex crosstalk between metabolic perturbations and inflammation underpinning fibrosis progression in MASLD.
Turku Bioscience Centre Is Recruiting New Research Leaders
Turku Bioscience Centre is currently inviting applications for two key research positions that will strengthen its internationally competitive bioscience research environment in Turku, Finland. We are seeking a…
The inflammatory path toward type 1 diabetes begins during pregnancy
Type 1 diabetes (T1D) is increasing globally, yet the earliest biological determinants remain poorly defined, particularly in general population studies. We studied the Swedish population-based ABIS birth cohort (n =…
Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an imaging and image-analysis…
Single-cell RNA-seq analysis of longitudinal CD4+ T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes
CONCLUSIONS: Our findings reveal early, cell-type-specific changes in transcription and gene regulatory networks in CD4⁺ T cells associated with type 1 diabetes progression, highlighting key pathways and transcriptional regulators. These…
Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Receptor tyrosine kinase ERBB4 (HER4) is frequently mutated in human cancer, and ERBB4 mutations have been identified in patients relapsing on targeted therapy. Here, we addressed the functional consequences of…
PhotoFiTT: a quantitative framework for assessing phototoxicity in live-cell microscopy experiments
Phototoxicity in live-cell fluorescence microscopy can compromise experimental outcomes, yet quantitative methods to assess its impact remain limited. Here, we present PhotoFiTT (Phototoxicity Fitness Time Trial), an integrated framework combining…
A resource to empirically establish drug exposure records directly from untargeted metabolomics data
Despite extensive efforts, extracting medication exposure information from clinical records remains challenging. To complement this approach, here we show the Global Natural Product Social Molecular Networking (GNPS) Drug Library, a…
Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity
Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health effects remain unclear. Here, we…