CONCLUSIONS: Features that differ between individuals with slow and rapid decline in β-cell mass could be valuable in staging and prediction of the rate of disease progression and thus enable…
The Research Council of Finland /Academy of Finland Scientific Council for Biosciences, Health and the Environment funding to two research projects at Turku Bioscience
The Research Council of Finland /Academy of Finland Scientific Council for Biosciences, Health and the Environment has granted generous funding to two research projects at Turku Bioscience: Half a million…
Cancer cell invasion alters the protein profile of extracellular vesicles
Extracellular vesicles (EVs) are important mediators of intercellular communication involved in local and long-range signalling of cancer metastasis. The onset of invasion is the key step of the metastatic cascade,…
SNM1A is crucial for efficient repair of complex DNA breaks in human cells
DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at…
Wnt/β-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst
Odontogenic tumors (OGTs), which originate from cells of odontogenic apparatus and their remnants, are rare entities. Primary intraosseous carcinoma NOS (PIOC), is one of the OGTs, but it is even…
Researchers discovered promising approach to prevent recurrence of breast cancer
Treatment outcomes for breast cancer have become better over the years, but proportion of breast cancers still recur even after long periods without signs of cancer remaining dormant in…
Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk
In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases,…
DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer cells transitioning from…
Improved breast milk proteome coverage by DIA based LC-MS/MS method
The breast milk composition includes a multitude of bioactive factors such as viable cells, lipids and proteins. Measuring the levels of specific proteins in breast milk plasma can be challenging…
Dissertation Defence: Dani Flinkman
Dani Flinkman defended his PhD entitled “Proteomics analysis of Parkinson’s disease mechanism and biomarkers” on May 17th. The opponent was Daniel Otzen from Aarhus University. Summary of the dissertation Parkinson’s…