The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult.
Serum lipidome associates with neuroimaging features in patients with traumatic brain injury
Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated…
Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice
CONCLUSIONS: The present data highlight the effect of hypoxia and Foxn1 on the protein profile and functionality of regenerative Foxn1^(-/-) DFs and demonstrate that the introduction of Foxn1 and Hif-1α…
Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis
The function of hydroxysteroid dehydrogenase 12 (HSD17B12) in lipid metabolism is poorly understood. To study this further, we created mice with hepatocyte-specific knockout of HSD17B12 (LiB12cKO). From 2 months on,…
Lower Plasma Levels of Selective VGF (Non-Acronymic) Peptides in Bipolar Disorder: Comparative Analysis Reveals Distinct Patterns across Mood Disorders and Healthy Controls
CONCLUSION: Our findings suggest that lower plasma levels of NAPP and AQEE are specifically associated with BD, thus possibly representing a diagnostic biomarker in mood disorders.
Young Investigator Award in immunology to Carlos Rogerio Figueiredo
InFLAMES group leader, Docent Carlos Rogerio Figueiredo, has received the Young Investigator Award from the Scandinavian Society for Immunology. The award was announced at the European Congress of Immunology in…
Autumn Frontiers of Science seminars start 12 September
Frontiers of Science seminar program is ready for autumn 2024. All seminars are on-site only at 12:00. Coffee and sandwich are served before each seminar. Frontiers of Science…
Intermediate filaments at a glance
Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular functions, including providing structural…
Emerging ctDNA detection strategies in clinical cancer theranostics
Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor-specific gene mutations and other valuable information. ctDNA is considered…