The immune system has emerged as a critical factor influencing neurodevelopment in offspring. While this is increasingly well-studied in the context of maternal immune activation (MIA), the relationship between postnatal…
Functionalized neutrophil nanovesicles for targeted photodynamic immunotherapy and potentiation of checkpoint blockade in colorectal cancer
Colorectal cancer (CRC) patients with microsatellite-stable tumors typically resist immune checkpoint blockade (ICB) due to an immunosuppressive “cold” microenvironment. Photodynamic therapy (PDT) generates reactive oxygen species (ROS) to ablate tumor…
A State-Gated Metallo-DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing
Stress-generating therapeutic materials are commonly optimized to deliver cytotoxic inputs, but delivery alone does not determine whether intracellular stress becomes irreversible damage. Tumor cells can buffer metal-, redox- and mitochondrial…
Integrating multi-omics technologies to decipher microbiome functions
Multi-omics approaches have revolutionized our understanding of microbial communities by enabling simultaneous interrogation of genomic, transcriptomic, proteomic, and metabolomic data. The systematic integration and analysis of these deep datasets help…
Lifestyle, anthropometric factors and clinically significant prostate cancer diagnosis in men with suspected prostate cancer
CONCLUSIONS: Higher measured physical activity was inversely associated with detection of csPCa in men with suspicion of PCa. Active smoking also showed an inverse association. Both findings merit further investigation.
Rxiv-Maker: An automated template engine for streamlined scientific publications
Preprints have transformed how biologists share results, yet how well a preprint reads still depends on formatting, a task that has shifted from publishers to authors. Cell biology has also…
CCT8 associates with the MYO10 motor domain and regulates filopodia and breast cancer cell invasion
Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover the molecular machinery underlying…
Dynamic micropatterning uncovers spatial dynamics of B cell immune synapse formation
In the process of mounting humoral immune responses, B cells typically engage antigens on the surface of antigen-presenting cells (APCs) via the immunological synapse (IS). To study this critical cell…
PFAS exposure alters gut microbiota metabolites associated with hepatic metabolism: a pilot study
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that can disrupt human hepatic metabolism both directly and through alterations of the gut microbiota. However, the contribution of microbiota-mediated mechanisms…
Proteomic insights into human induced regulatory T cells: the role of LPXN and CD160 in immune suppression
Regulatory T cells (Treg) play a central role in maintaining immune homeostasis, and the implementation of in vitro induced Treg cells (iTreg) to control immune function has significant potential in…