Preprints have transformed how biologists share results, yet how well a preprint reads still depends on formatting, a task that has shifted from publishers to authors. Cell biology has also…
CCT8 associates with the MYO10 motor domain and regulates filopodia and breast cancer cell invasion
Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover the molecular machinery underlying…
Dynamic micropatterning uncovers spatial dynamics of B cell immune synapse formation
In the process of mounting humoral immune responses, B cells typically engage antigens on the surface of antigen-presenting cells (APCs) via the immunological synapse (IS). To study this critical cell…
PFAS exposure alters gut microbiota metabolites associated with hepatic metabolism: a pilot study
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that can disrupt human hepatic metabolism both directly and through alterations of the gut microbiota. However, the contribution of microbiota-mediated mechanisms…
Proteomic insights into human induced regulatory T cells: the role of LPXN and CD160 in immune suppression
Regulatory T cells (Treg) play a central role in maintaining immune homeostasis, and the implementation of in vitro induced Treg cells (iTreg) to control immune function has significant potential in…
In Situ Biomineralization Enhances Mitochondrial Transplantation to Differentiating Osteoclast Precursors for Suppressing Cancer-Induced Osteolysis
Cancer-induced bone osteolysis is a common complication of multiple malignancies and may actively contribute to bone metastasis. Its core pathology is closely associated with mitochondrial metabolic dysfunction during osteoclast differentiation.
NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations
Integrating tissue-level organisation with sub-cellular resolution and molecular information often requires combining multiple microscopy modalities and scales. However, aligning images acquired with different modalities, settings, or instruments remains challenging. Here,…
Performance of a next-generation rapid lipoarabinomannan urine assay for tuberculosis in outpatients with and without HIV in South Africa and Uganda: a two-centre diagnostic accuracy study
BACKGROUND: Non-sputum-based tuberculosis tests are a global priority because sputum-dependent diagnostics systematically miss populations at highest risk of disease, including people living with HIV. We evaluated the diagnostic accuracy of…
Using NIR-emitting MgO:Li,Ce,Sm microparticles in the preparation of biophotonic glass – a promising approach to enable optical NIR imaging
One significant challenge in working with reconstructive bioactive glass implants is the difficulty in postoperative imaging, due to their density being very similar to that of bone. One possibility to…