Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models 3 December 2025
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson’s Disease Models 3 December 2025
Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element 3 December 2025
A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs 3 December 2025
Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields 3 December 2025
ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability 3 December 2025
Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators 3 December 2025
Disruption of nNOS–NOS1AP protein–protein interactions suppresses neuropathic pain in mice 3 December 2025
Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 3 December 2025
