Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis

Heba Nabil, Mahmoud-Sobhy Elkhwanky, Mohamed Hassanen, Einari A. Niskanen, Raghavendra Mysore, Jorma J. Palvimo, Outi Kummu, Jukka Hakkola

Archives of Toxicology (2026)

Published on January 30, 2026

DOI: https://doi.org/10.1007/s00204-025-04280-0

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O. Parilova et al. • 2026 • Nucleic Acids Research
Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity... Read more
M. Gluud et al. • 2026 • Allergy
ABSTRACT Background Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T‐cell lymphoma... Read more
G. Follain et al. • 2026 • The EMBO Journal
Abstract The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these... Read more