Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes

    Santosh Lamichhane, Partho Sen, Alex M. Dickens, Marina Amaral Alves, Taina Härkönen, Jarno Honkanen, Tommi Vatanen, Ramnik J. Xavier, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič

    Cell Reports Medicine (2022)

    Published on December 3, 2025

    DOI: https://doi.org/10.1016/j.xcrm.2022.100762

    Core: Metabolomics
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    December 3, 2025
    Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children
    Santosh Lamichhane, Partho Sen, Alex M. Dickens, Matilda Kråkström, Jorma Ilonen, Johanna Lempainen, Heikki Hyöty, Riitta Lahesmaa, Riitta Veijola, Jorma Toppari, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič Frontiers in Endocrinology (2023)
    Aims/hypothesisAppearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however,...
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