Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth

    Opeyemi Olotu, Anna-Riina Koskenniemi, Lin Ma, Valeriy Paramonov, Sini Laasanen, Elina Louramo, Matthieu Bourgery, Tiina Lehtiniemi, Samuli Laasanen, Adolfo Rivero-Müller, Eliisa Löyttyniemi, Cecilia Sahlgren, Jukka Westermarck, Sami Ventelä, Tapio Visakorpi, Matti Poutanen, Paula Vainio, Juho-Antti Mäkelä, Noora Kotaja

    Cell Reports (2024)

    Published on December 3, 2025

    DOI: https://doi.org/10.1016/j.celrep.2024.114430

    Core: Advanced Imaging Core
    ← Back to Publications
    Genes associated with immune response are upregulated in clinically healthy skin of patients with gliptin-associated bullous pemphigoid
    N. Kokkonen et al. • 2026 • Journal of Investigative Dermatology
    Core:Finnish Functional Genomics Centre
    Read more
    Improving genotyped functional screening: A versatile closed-tube PCR for Illumina library generation reduces background sequences in multiplexed sequencing
    S. Oksanen et al. • 2026 • SLAS Technology
    Core:Finnish Functional Genomics Centre
    Read more
    Dynamic landscape of transcription initiation by yeast RNA polymerase I
    O. Parilova et al. • 2026 • Nucleic Acids Research
    Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity...
    Core:Protein Structure and Chemistry
    Read more
    Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
    M. Gluud et al. • 2026 • Allergy
    ABSTRACT Background Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T‐cell lymphoma...
    Core:Cytometry Core
    Read more
    Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
    G. Follain et al. • 2026 • The EMBO Journal
    Abstract The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these...
    Core:Advanced Imaging Core
    Read more
    All user publications

    More User Publications

    User Publication
    December 4, 2025
    Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na
    Jenni H.E. Mäki-Jouppila, Leena J. Laine, Jonathan Rehnberg, Elli Narvi, Pekka Tiikkainen, Elvira Hukasova, Pasi Halonen, Arne Lindqvist, Lila Kallio, Antti Poso, Marko J. Kallio Molecular Cancer Therapeutics (2014)
    Abstract Mitosis is an attractive target for the development of new anticancer drugs. In a search for novel mitotic inhibitors,...
    Read abstract