Improving the knock-in efficiency of the MOF-encapsulated CRISPR/Cas9 system through controllable embedding structures

    Chang Liu, Xiaoyu Xu, Oliver Koivisto, Wenhui Zhou, Guillaume Jacquemet, Jessica M. Rosenholm, Hongbo Zhang

    Nanoscale (2021)

    Published on December 4, 2025

    DOI: https://doi.org/10.1039/d1nr02872c

    Core: Advanced Imaging Core

    Abstract

    A rapid and convenient method was developed to load gene molecules into nanostructures, exploring structure–function relationship for efficient intracellular delivery and gene editing, opening up new avenues for the MOF-based non-viral vectors.
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