PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion

    Sebastian K.J. Landor, Niina M. Santio, William B. Eccleshall, Valeriy M. Paramonov, Ellen K. Gagliani, Daniel Hall, Shao-Bo Jin, Käthe M. Dahlström, Tiina A. Salminen, Adolfo Rivero-Müller, Urban Lendahl, Rhett A. Kovall, Päivi J. Koskinen, Cecilia Sahlgren

    Journal of Biological Chemistry (2021)

    Published on December 4, 2025

    DOI: https://doi.org/10.1016/j.jbc.2021.100593

    Core: Advanced Imaging Core
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    Genes associated with immune response are upregulated in clinically healthy skin of patients with gliptin-associated bullous pemphigoid
    N. Kokkonen et al. • 2026 • Journal of Investigative Dermatology
    Core:Finnish Functional Genomics Centre
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    Improving genotyped functional screening: A versatile closed-tube PCR for Illumina library generation reduces background sequences in multiplexed sequencing
    S. Oksanen et al. • 2026 • SLAS Technology
    Core:Finnish Functional Genomics Centre
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    Dynamic landscape of transcription initiation by yeast RNA polymerase I
    O. Parilova et al. • 2026 • Nucleic Acids Research
    Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity...
    Core:Protein Structure and Chemistry
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    Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
    M. Gluud et al. • 2026 • Allergy
    ABSTRACT Background Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T‐cell lymphoma...
    Core:Cytometry Core
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    Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
    G. Follain et al. • 2026 • The EMBO Journal
    Abstract The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these...
    Core:Advanced Imaging Core
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