Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity
Dev Cell. 2025 Jun 23;60(12):1655-1657. doi: 10.1016/j.devcel.2025.05.015.
Published on June 24, 2025
ABSTRACT
In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.
PMID:40555172 | DOI:10.1016/j.devcel.2025.05.015
Latest Publications
- Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties
- Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome
- Embigin is involved in the regulation of early mouse kidney development
- Complete Data Analysis Workflow for Quantitative DIA Mass Spectrometry Using Nextflow
- Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe