HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion 

Jenny C Pessa et al.

Sci Adv. 2025 Sep 5;11(36):eady1289. doi: 10.1126/sciadv.ady1289. Epub 2025 Sep 3.

Published on September 3, 2025

Breast cancer is hallmarked by phenotypic transitions enabling abnormal cell proliferation and invasion. The stress-protective transcription factor heat shock factor 2 (HSF2) is associated with Read more

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index 

Timo Seitz et al.

Mol Nutr Food Res. 2025 Sep 1:e70225. doi: 10.1002/mnfr.70225. Online ahead of print.

Published on September 2, 2025

Breast milk proteome comprises hundreds of bioactive proteins supporting infant development. The extent to which maternal metabolic conditions modify the proteome is poorly known. This Read more

Metabolome informs about the chemical exposome and links to brain health 

Matej Orešič et al.

Environ Int. 2025 Aug 22;203:109741. doi: 10.1016/j.envint.2025.109741. Online ahead of print.

Published on September 1, 2025

The metabolome is an intermediate phenotype, summarizing the profile of all small molecules (

Designing Fluorescent Estrogen Mimetic 7-hydroxycoumarin Probe Substrates for Human Sulfotransferase Enzymes 

Risto O Juvonen et al.

Eur J Pharm Sci. 2025 Aug 28:107249. doi: 10.1016/j.ejps.2025.107249. Online ahead of print.

Published on August 30, 2025

Sulfonation is one of drug metabolism reactions affecting homeostasis of estrogens. C-3 aryl substituted 7-hydroxycoumarins are fluorescent estrogen mimetics; i.e., the hydroxyl groups of both Read more

Cholesterol Ester Storage Disease in Two Field Spaniels With Lysosomal Acid Lipase Deficiency 

Pernilla Syrjä et al.

J Vet Intern Med. 2025 Sep-Oct;39(5):e70223. doi: 10.1111/jvim.70223.

Published on August 27, 2025

Cholesterol ester storage disease (CESD) is a rare genetic lysosomal storage disorder resulting from lower lysosomal acid lipase (LAL) activity. LAL is an essential enzyme Read more

The impact of conjugation strategies and linker density on the performance of the Spermine-AcDex nanoparticle-splenocyte conjugate 

Yuchen Su et al.

RSC Chem Biol. 2025 Jul 30. doi: 10.1039/d5cb00104h. Online ahead of print.

Published on August 18, 2025

A common approach in living medicine engineering is modifying cell surfaces with nanomedicines to form nanoparticle-cell conjugates. Despite various available strategies, limited research has examined Read more

A systematic approach to study the effects of acquisition parameters and biological factors on computerized mammography analysis using ex vivo human tissue: A protocol description 

Nicole Hernández et al.

PLoS One. 2025 Aug 18;20(8):e0321658. doi: 10.1371/journal.pone.0321658. eCollection 2025.

Published on August 18, 2025

BACKGROUND: Mammography is the most common imaging modality for the detection of breast cancer. Artificial intelligence algorithms for mammography analysis have shown promising performance for Read more

Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat 

Herbert Michlmayr et al.

J Biol Chem. 2025 Aug 14:110600. doi: 10.1016/j.jbc.2025.110600. Online ahead of print.

Published on August 16, 2025

Deoxynivalenol (DON) is a toxicologically relevant trichothecene mycotoxin frequently found in cereal products. It is a virulence factor produced by the plant pathogen Fusarium graminearum Read more

Pharmacokinetics, Metabolism, and Toxicity of Anisomelic Acid and Ovatodiolide: Guiding Route of Administration in Preclinical Studies 

Navid Delshad et al.

Eur J Pharm Sci. 2025 Aug 12:107235. doi: 10.1016/j.ejps.2025.107235. Online ahead of print.

Published on August 14, 2025

Despite extensive progress in cancer therapeutic research, translating promising anticancer compounds into clinical treatments often fails due to suboptimal pharmacokinetic and safety profiles. These shortcomings Read more

Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy 

Stuart Prince et al.

Theranostics. 2025 Jun 23;15(15):7501-7527. doi: 10.7150/thno.110544. eCollection 2025.

Published on August 4, 2025

Rationale: Clever-1 is a multifunctional scavenger receptor that promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. Its high expression correlates with resistance to Read more

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB-inhibitor-induced phenotypes 

Katri Vaparanta et al.

FEBS J. 2025 Jul 24. doi: 10.1111/febs.70197. Online ahead of print.

Published on July 24, 2025

The impact of kinase inhibitors on the phosphoproteome has been rarely investigated at a whole-organism level. Here, we performed a phosphoproteomic analysis in embryonic zebrafish Read more

Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial 

Edward Chesney et al.

Neuropsychopharmacology. 2025 Jul 24. doi: 10.1038/s41386-025-02175-3. Online ahead of print.

Published on July 23, 2025

In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment Read more