Publications

    PUBLICATION

    Disrupting Complement-Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation 

    Yu Zhang et al.

    Adv Mater. 2025 Nov 28:e18378. doi: 10.1002/adma.202518378. Online ahead of print.

    Published on November 28, 2025

    The positive feedback circuit between the complement system and inflammatory immune responses maps the malignant progression of chronic joint inflammation. Prolonged dysregulation of the immune Read more

    PUBLICATION

    Vimentin in the tumor microenvironment: orchestrating invasion, immunity, and metabolism 

    Sepideh Parvanian et al.

    Eur J Cell Biol. 2025 Nov 21;104(4):151523. doi: 10.1016/j.ejcb.2025.151523. Online ahead of print.

    Published on November 27, 2025

    Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of Read more

    PUBLICATION

    Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles 

    Shrikant B Kokate et al.

    Curr Biol. 2025 Nov 25:S0960-9822(25)01462-9. doi: 10.1016/j.cub.2025.10.081. Online ahead of print.

    Published on November 26, 2025

    Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their Read more

    PUBLICATION

    Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase 

    Charoutioun S Bodourian et al.

    Protein Sci. 2025 Dec;34(12):e70396. doi: 10.1002/pro.70396.

    Published on November 26, 2025

    The 16S microbial community profiling of a metagenomics library from geothermal spring at Lisvori (Lesvos island, Greece) enabled the identification of a putative sequence exhibiting Read more

    PUBLICATION

    Dynamics of gut metabolome and microbiota maturation during early life 

    Anna-Katariina Aatsinki et al.

    iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21.

    Published on November 24, 2025

    Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This Read more

    PUBLICATION

    Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation 

    Thinh Thi Kim Truong et al.

    J Oral Biosci. 2025 Dec;67(4):100691. doi: 10.1016/j.job.2025.100691. Epub 2025 Aug 19.

    Published on November 22, 2025

    CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression Read more

    PUBLICATION

    Hepatic zonation determines tumorigenic potential of mutant β-catenin 

    Alexander Raven et al.

    Nature. 2025 Nov 19. doi: 10.1038/s41586-025-09733-1. Online ahead of print.

    Published on November 19, 2025

    Oncogenic mutations in phenotypically normal tissue are common across adult organs^(1,2). This suggests that multiple events need to converge to drive tumorigenesis and that many Read more

    PUBLICATION

    Breast cancer remodels lymphatics in sentinel lymph nodes 

    Dominik Eichin et al.

    Nat Commun. 2025 Nov 17;16(1):10056. doi: 10.1038/s41467-025-64981-z.

    Published on November 17, 2025

    Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis Read more

    PUBLICATION

    LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation 

    Ubaid Ullah Kalim et al.

    iScience. 2025 Oct 15;28(11):113779. doi: 10.1016/j.isci.2025.113779. eCollection 2025 Nov 21.

    Published on November 17, 2025

    Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and Read more

    PUBLICATION

    Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration 

    António G G Sousa et al.

    Nucleic Acids Res. 2025 Nov 13;53(21):gkaf1128. doi: 10.1093/nar/gkaf1128.

    Published on November 16, 2025

    Complex single-cell analyses now routinely integrate multiple datasets, followed by cell-type annotation and differential expression analysis. Current state-of-the-art integration methods often struggle with imbalanced cell Read more

    PUBLICATION

    Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis 

    Tiit Örd et al.

    Cardiovasc Res. 2025 Nov 7:cvaf210. doi: 10.1093/cvr/cvaf210. Online ahead of print.

    Published on November 9, 2025

    CONCLUSIONS: Our findings provide novel insights into macrophage-specific gene programs during atherosclerosis progression and identify a set of promising biomarkers that can serve as a Read more

    PUBLICATION

    Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma 

    Jie Bao et al.

    Biomed Pharmacother. 2025 Nov 6;193:118716. doi: 10.1016/j.biopha.2025.118716. Online ahead of print.

    Published on November 7, 2025

    Ovarian high-grade serous cancer (HGSC) is the most aggressive ovarian cancer subtype with limited treatment options. We identify the PDPK1 inhibitor BX-912 as a promising Read more