Pharmacokinetics, Metabolism, and Toxicity of Anisomelic Acid and Ovatodiolide: Guiding Route of Administration in Preclinical Studies 

Navid Delshad et al.

Eur J Pharm Sci. 2025 Aug 12:107235. doi: 10.1016/j.ejps.2025.107235. Online ahead of print.

Published on August 14, 2025

Despite extensive progress in cancer therapeutic research, translating promising anticancer compounds into clinical treatments often fails due to suboptimal pharmacokinetic and safety profiles. These shortcomings Read more

Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy 

Stuart Prince et al.

Theranostics. 2025 Jun 23;15(15):7501-7527. doi: 10.7150/thno.110544. eCollection 2025.

Published on August 4, 2025

Rationale: Clever-1 is a multifunctional scavenger receptor that promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. Its high expression correlates with resistance to Read more

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB-inhibitor-induced phenotypes 

Katri Vaparanta et al.

FEBS J. 2025 Jul 24. doi: 10.1111/febs.70197. Online ahead of print.

Published on July 24, 2025

The impact of kinase inhibitors on the phosphoproteome has been rarely investigated at a whole-organism level. Here, we performed a phosphoproteomic analysis in embryonic zebrafish Read more

Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial 

Edward Chesney et al.

Neuropsychopharmacology. 2025 Jul 24. doi: 10.1038/s41386-025-02175-3. Online ahead of print.

Published on July 23, 2025

In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment Read more

Correction: The PP2A regulator IER5L supports prostate cancer progression 

Jana R Crespo et al.

Cell Death Dis. 2025 Jul 22;16(1):545. doi: 10.1038/s41419-025-07802-x.

Published on July 22, 2025

No abstract

LIMA1-alpha staining predicts curative intent surgery response in HPV negative head and neck cancer 

Xi Qiao et al.

EMBO Mol Med. 2025 Jul 17. doi: 10.1038/s44321-025-00266-8. Online ahead of print.

Published on July 17, 2025

In many solid cancer types, surgery alone could be a sufficient first therapy option for a significant number of cancer patients. However, there are currently Read more

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration 

Niklas Z Jäntti et al.

Dev Cell. 2025 Jul 9:S1534-5807(25)00403-4. doi: 10.1016/j.devcel.2025.06.025. Online ahead of print.

Published on July 16, 2025

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles Read more

Extracellular vesicles bearing vimentin drive epithelial-mesenchymal transition 

Sepideh Parvanian et al.

Mol Cell Proteomics. 2025 Jul 4:101028. doi: 10.1016/j.mcpro.2025.101028. Online ahead of print.

Published on July 6, 2025

Epithelial-mesenchymal transition (EMT) is a key biological process in physiological and pathological conditions, spanning development, wound healing, and cancer. Vimentin, a key cytoskeletal intermediate filament Read more

Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy 

Afonso Mendes et al.

Nat Commun. 2025 Jul 1;16(1):5767. doi: 10.1038/s41467-025-60709-1.

Published on July 2, 2025

From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While super-resolution microscopy can Read more

Sketching T cell atlases in the single-cell era: challenges and recommendations 

Itana Bojović et al.

Immunol Cell Biol. 2025 Jun 29. doi: 10.1111/imcb.70040. Online ahead of print.

Published on June 29, 2025

Recent advances in single-cell technologies have enabled the creation of comprehensive cell atlases, reference maps of various cell types within organisms. Here we specifically focus Read more

In situ construction of ossification micro-units for critical bone regeneration via sustained lifting of epigenetic suppression 

Wu Yang et al.

J Control Release. 2025 Jun 23:113978. doi: 10.1016/j.jconrel.2025.113978. Online ahead of print.

Published on June 25, 2025

Critical-sized bone defects present significant clinical challenges due to insufficient stem cell recruitment, epigenetic suppression of osteogenesis, and inadequate mineralization. Among the epigenetic suppression mechanisms, Read more

Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity 

John E Eriksson et al.

Dev Cell. 2025 Jun 23;60(12):1655-1657. doi: 10.1016/j.devcel.2025.05.015.

Published on June 24, 2025

In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes Read more