Publications

    Phosphoproteomic analysis reveals the diversity of signaling behind ErbB-inhibitor-induced phenotypes 

    Katri Vaparanta et al.

    FEBS J. 2025 Jul 24. doi: 10.1111/febs.70197. Online ahead of print.

    Published on July 24, 2025

    The impact of kinase inhibitors on the phosphoproteome has been rarely investigated at a whole-organism level. Here, we performed a phosphoproteomic analysis in embryonic zebrafish Read more

    Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial 

    Edward Chesney et al.

    Neuropsychopharmacology. 2025 Jul 24. doi: 10.1038/s41386-025-02175-3. Online ahead of print.

    Published on July 23, 2025

    In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment Read more

    Correction: The PP2A regulator IER5L supports prostate cancer progression 

    Jana R Crespo et al.

    Cell Death Dis. 2025 Jul 22;16(1):545. doi: 10.1038/s41419-025-07802-x.

    Published on July 22, 2025

    No abstract

    LIMA1-alpha staining predicts curative intent surgery response in HPV negative head and neck cancer 

    Xi Qiao et al.

    EMBO Mol Med. 2025 Jul 17. doi: 10.1038/s44321-025-00266-8. Online ahead of print.

    Published on July 17, 2025

    In many solid cancer types, surgery alone could be a sufficient first therapy option for a significant number of cancer patients. However, there are currently Read more

    EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration 

    Niklas Z Jäntti et al.

    Dev Cell. 2025 Jul 9:S1534-5807(25)00403-4. doi: 10.1016/j.devcel.2025.06.025. Online ahead of print.

    Published on July 16, 2025

    Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles Read more

    Extracellular vesicles bearing vimentin drive epithelial-mesenchymal transition 

    Sepideh Parvanian et al.

    Mol Cell Proteomics. 2025 Jul 4:101028. doi: 10.1016/j.mcpro.2025.101028. Online ahead of print.

    Published on July 6, 2025

    Epithelial-mesenchymal transition (EMT) is a key biological process in physiological and pathological conditions, spanning development, wound healing, and cancer. Vimentin, a key cytoskeletal intermediate filament Read more

    Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy 

    Afonso Mendes et al.

    Nat Commun. 2025 Jul 1;16(1):5767. doi: 10.1038/s41467-025-60709-1.

    Published on July 2, 2025

    From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While super-resolution microscopy can Read more

    Sketching T cell atlases in the single-cell era: challenges and recommendations 

    Itana Bojović et al.

    Immunol Cell Biol. 2025 Jun 29. doi: 10.1111/imcb.70040. Online ahead of print.

    Published on June 29, 2025

    Recent advances in single-cell technologies have enabled the creation of comprehensive cell atlases, reference maps of various cell types within organisms. Here we specifically focus Read more

    In situ construction of ossification micro-units for critical bone regeneration via sustained lifting of epigenetic suppression 

    Wu Yang et al.

    J Control Release. 2025 Jun 23:113978. doi: 10.1016/j.jconrel.2025.113978. Online ahead of print.

    Published on June 25, 2025

    Critical-sized bone defects present significant clinical challenges due to insufficient stem cell recruitment, epigenetic suppression of osteogenesis, and inadequate mineralization. Among the epigenetic suppression mechanisms, Read more

    Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity 

    John E Eriksson et al.

    Dev Cell. 2025 Jun 23;60(12):1655-1657. doi: 10.1016/j.devcel.2025.05.015.

    Published on June 24, 2025

    In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes Read more

    Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions 

    Maria E Taskinen et al.

    Stem Cell Reports. 2025 Jun 17:102538. doi: 10.1016/j.stemcr.2025.102538. Online ahead of print.

    Published on June 20, 2025

    Integrin β1-mediated adhesion is dispensable in early mouse embryogenesis (pre-implantation) but indispensable post-implantation, suggesting distinct roles for β1-integrin-mediated adhesions in the naive (pre-implantation) versus primed Read more

    The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria 

    Praveen Mallari et al.

    Pharm Res. 2025 Jun 16. doi: 10.1007/s11095-025-03871-x. Online ahead of print.

    Published on June 16, 2025

    CONCLUSION: Despite the substantial obstacles to getting bench findings to the patient, numerous scientists are still working towards this goal. Both the application of antibiotic Read more