Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity 

    John E Eriksson et al.

    Dev Cell. 2025 Jun 23;60(12):1655-1657. doi: 10.1016/j.devcel.2025.05.015.

    Published on June 24, 2025

     

    ABSTRACT

    In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.

    PMID:40555172 | DOI:10.1016/j.devcel.2025.05.015

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