Inhibition of tumor suppressor Protein Phosphatase 2A (PP2A) has been denoted as one of the minimal requirements for malignant transformation of a human cell. In cancer, PP2A activity is in the majority of cases inhibited by the overexpression of the endogenous PP2A inhibitor proteins (PAIPs), such as CIP2A, ARPP19, SET, PME-1 and TIPRL. In this thesis, PP2A inhibition by the PAIPs was elaborated in acute and chronic myeloid leukemias (AML and CML) and head and neck squamous cell carcinoma (HNSCC). Moreover, the ability of the PAIPs to act as clinically relevant cancer biomarkers was investigated.

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Eleonora Mäkelä will have public defense for her Doctoral Dissertation ”Novel PP2A biomarkers in cancer” at University of Turku, on Friday April 9th, 2021 at 12 noon.

The opponent is Professor Kimmo Porkka (University of Helsinki) and custos Professor Jukka Westermarck (University of Turku). The event is in English. The area of doctoral dissertation is Pathology.

Due to COVID-19 situation dissertation defences are not arranged as open audience events. Audience can participate via remote connection.

Zoom link for the event: https://utu.zoom.us/j/65079017741
Passcode: 761246

PhD dissertation in electronic form: https://www.utupub.fi/handle/10024/151245
Press release (in Finnish): https://www.utu.fi/fi/ajankohtaista/vaitos/uusia-mahdollisuuksia-syopahoitojen-toimivuuden-ennustamiseen