October 10^th at 12:00
Onsite event
in Presidentti auditorium, BioCity

Prof. Steffen Jung, the Weizmann Institute of Science’s Department of Immunology, Israel
Monocytes and macrophages – when origins matter
Host: Alex Mildner (alexander.mildner@utu.fi)

Coffee and sandwich at 11:45, first come first served!

Six PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Jung after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

Mononuclear phagocytes form a body-wide network of myeloid immune cells devoted to homeostasis maintenance and the immune defense of the organism. The Jung Lab studies these monocytes, dendritic cells and macrophages in physiology and pathophysiology using gene expression and epigenome profiling, as well as a combination of conditional mutagenesis, in vivo cell imaging, cell ablation and cell transfer strategies. Current focus is given to monocytes, as well as macrophages in the gut, lung and brain. Specifically, The Jung Lab uses small animal models to investigate contributions of these cells to inflammatory bowel disease, endometriosis and the role of microglia, monocyte-derived macrophages and perivascular brain cells in neuro-inflammation and -degeneration, as well as aging.

Selected publications

Sekeresova Kralova J, Donic C, Dassa B, …, Shlezinger N, Jung S. 2024. Competitive fungal commensalism mitigates candidiasis pathology. J Exp Med. 221(5):e20231686. doi: 10.1084/jem.20231686.

De Schepper S, Ge JZ, Crowley G, Ferreira LSS, Garceau D, Toomey CE, Sokolova D, Rueda-Carrasco J, Shin SH, Kim JS, Childs T, Lashley T, Burden JJ, Sasner M, Sala Frigerio C, Jung S, Hong S. 2023. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease. Nat Neurosci. 26(3):406-415. doi: 10.1038/s41593-023-01257-z.

Haimon Z, Frumer GR, Kim JS, Trzebanski S, Haffner-Krausz R, Ben-Dor S, Porat Z, Muschaweckh A, Chappell-Maor L, Boura-Halfon S, Korn T, Jung S. 2022. Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology. Nat Immunol. 23(12):1749-1762. doi: 10.1038/s41590-022-01360-6.

Kim JS, Kolesnikov M, Peled-Hajaj S, Scheyltjens I, Xia Y, Trzebanski S, Haimon Z, Shemer A, Lubart A, Van Hove H, Chappell-Maor L, Boura-Halfon S, Movahedi K, Blinder P, Jung S. 2021. A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages. Immunity. 54(1):176-190.e7. doi: 10.1016/j.immuni.2020.11.007.

General information

• You can download and save all the autumn 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Registration is not needed, participation list is circulated in the audience
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Autumn 2024 image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image created in the PyMOL Molecular Graphics System, Version 2.5 Schrödinger, LLC.