Publications & Acknowledgements

    Genome Editing Core

    Selected publications by the our core facility users

    Publications 2023

    <scp>PP2A</scp> ‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

    Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina von Schantz‐Fant, Michael Ohlmeyer, Krister Wennerberg, Otto Kauko, Raphael Koch, Tero Aittokallio, Mikko Taipale, Jukka Westermarck
    Molecular Oncology

    Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase...
    https://doi.org/10.1002/1878-0261.13488

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    <scp>PP2A</scp> methylesterase <scp>PME</scp> ‐1 suppresses anoikis and is associated with therapy relapse of <scp> <i>PTEN</i> </scp> ‐deficient prostate cancers

    Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song‐Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck
    Molecular Oncology

    While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge. Resistance to...
    https://doi.org/10.1002/1878-0261.13353

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    Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling

    James R. W. Conway, Aleksi Isomursu, Gautier Follain, Ville Härmä, Eva Jou-Ollé, Nicolas Pasquier, Eetu P. O. Välimäki, Juha K. Rantala, Johanna Ivaska
    Proceedings of the National Academy of Sciences

    Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to...
    https://doi.org/10.1073/pnas.2304288120

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    HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function

    Syed Bilal Ahmad Andrabi, Kedar Batkulwar, Santosh D. Bhosale, Robert Moulder, Meraj Hasan Khan, Tanja Buchacher, Mohd Moin Khan, Ilona Arnkil, Omid Rasool, Alexander Marson, Ubaid Ullah Kalim, Riitta Lahesmaa
    Immunology Letters
    https://doi.org/10.1016/j.imlet.2023.09.001

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    IGFBP2 secretion by mammary adipocytes limits breast cancer invasion

    James R. W. Conway, Defne D. Dinç, Gautier Follain, Oona Paavolainen, Jasmin Kaivola, Pia Boström, Pauliina Hartiala, Emilia Peuhu, Johanna Ivaska
    Science Advances

    The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a...
    https://doi.org/10.1126/sciadv.adg1840

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    Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394

    Elina Siljamäki, Pilvi Riihilä, Ujjwal Suwal, Liisa Nissinen, Pekka Rappu, Markku Kallajoki, Veli-Matti Kähäri, Jyrki Heino
    Oncogene

    AbstractCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of patients with metastatic cSCC is...
    https://doi.org/10.1038/s41388-023-02863-8

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    Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

    Laura Virtanen, Emilia Holm, Mona Halme, Gun West, Fanny Lindholm, Josef Gullmets, Juho Irjala, Tiina Heliö, Artur Padzik, Annika Meinander, John E. Eriksson, Pekka Taimen
    Journal of Cell Science

    ABSTRACT The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by the...
    https://doi.org/10.1242/jcs.259788

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    Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

    Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
    Nature Communications

    AbstractThe protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer...
    https://doi.org/10.1038/s41467-023-36693-9

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