Genome Editing Core Publications

Publications & Acknowledgements

Selected publications by the our core facility users

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Publications 2023

<scp>PP2A</scp> ‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina von Schantz‐Fant, Michael Ohlmeyer, Krister Wennerberg, Otto Kauko, Raphael Koch, Tero Aittokallio, Mikko Taipale, Jukka Westermarck
Molecular Oncology (2023)

Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase...

https://doi.org/10.1002/1878-0261.13488

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<scp>PP2A</scp> methylesterase <scp>PME</scp> ‐1 suppresses anoikis and is associated with therapy relapse of <scp> <i>PTEN</i> </scp> ‐deficient prostate cancers

Core:Genome Editing Core

Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song‐Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck
Molecular Oncology (2023)

While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge. Resistance to...

https://doi.org/10.1002/1878-0261.13353

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Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling

Core:Genome Editing Core

James R. W. Conway, Aleksi Isomursu, Gautier Follain, Ville Härmä, Eva Jou-Ollé, Nicolas Pasquier, Eetu P. O. Välimäki, Juha K. Rantala, Johanna Ivaska
Proceedings of the National Academy of Sciences (2023)

Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to...

https://doi.org/10.1073/pnas.2304288120

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HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function

Core:Genome Editing Core

Syed Bilal Ahmad Andrabi, Kedar Batkulwar, Santosh D. Bhosale, Robert Moulder, Meraj Hasan Khan, Tanja Buchacher, Mohd Moin Khan, Ilona Arnkil, Omid Rasool, Alexander Marson, Ubaid Ullah Kalim, Riitta Lahesmaa
Immunology Letters (2023)
https://doi.org/10.1016/j.imlet.2023.09.001

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IGFBP2 secretion by mammary adipocytes limits breast cancer invasion

Core:Genome Editing Core

James R. W. Conway, Defne D. Dinç, Gautier Follain, Oona Paavolainen, Jasmin Kaivola, Pia Boström, Pauliina Hartiala, Emilia Peuhu, Johanna Ivaska
Science Advances (2023)

The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a...

https://doi.org/10.1126/sciadv.adg1840

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Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394

Core:Genome Editing Core

Elina Siljamäki, Pilvi Riihilä, Ujjwal Suwal, Liisa Nissinen, Pekka Rappu, Markku Kallajoki, Veli-Matti Kähäri, Jyrki Heino
Oncogene (2023)

AbstractCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of patients with metastatic cSCC is...

https://doi.org/10.1038/s41388-023-02863-8

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Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

Core:Genome Editing Core

Laura Virtanen, Emilia Holm, Mona Halme, Gun West, Fanny Lindholm, Josef Gullmets, Juho Irjala, Tiina Heliö, Artur Padzik, Annika Meinander, John E. Eriksson, Pekka Taimen
Journal of Cell Science (2023)

ABSTRACT The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by the...

https://doi.org/10.1242/jcs.259788

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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Core:Genome Editing Core

Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Nature Communications (2023)

AbstractThe protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer...

https://doi.org/10.1038/s41467-023-36693-9

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