February 1^st at 14:00
Virtual event
Flyer

Jenny Mjösberg, Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet: Tissue- and inflammation-specific imprinting of human innate lymphoid cells

Register latest Jan 31^st at 12.00: https://link.webropolsurveys.com/S/60ED5C13513358D0
Zoom link and iCalendar invitation to join the online event will be sent to all registered participants one day before the event.

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi), University of Turku.

Jenny Mjösberg is an associate professor at the Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden. She earned her PhD in reproductive immunology at Linköping University, Sweden, in 2010. During her postdoc period in the lab of Hergen Spits at the AMC, Amsterdam, she contributed to the discovery of two novel subsets of human ILCs; ILC2 and ILC1. Since 2013, research in her own lab at CIM is focused on the importance of human ILCs in mucosal homeostasis and inflammation, mainly in the lung and gastrointestinal tract. Importantly, in 2016 Mjösberg provided the first transcriptional characterization of human ILCs on the single-cell level. These studies, along with continued transcriptional and epigenetic dissection of ILCs across several human organs have revealed previously unknown heterogeneity and a plethora of characteristics and regulatory mechanisms that control the function of specific ILC subsets. Her group ultimately aims at understanding the role of ILCs in asthma and gastrointestinal disease, including colorectal cancer and inflammatory bowel disease, for the development of novel therapeutic concepts.

Selected publications:

1. Mazzurana L, Czarnewski P, Jonsson V, Wigge L, Ringnér M, Williams TC, Ravindran A, Björklund ÅK, Säfholm J, Nilsson G, Dahlén SE, Orre AC, Al-Ameri M, Höög C, Hedin C, Szczegielniak S, Almer S, Mjösberg J. Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing. Cell Res. 2021 Jan 8. doi: 10.1038/s41422-020-00445-x.
2. Rao A, Strauss O, Kokkinou E, Bruchard M, Tripathi KP, Schlums H, Carrasco A, Mazzurana L, Konya V, Villablanca EJ, Björkström NK, Lindforss U, Spits H, Mjösberg J. Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs. Nat Commun. 2020 Apr 27;11(1):2049.
3. Maric J, Ravindran A, Mazzurana L, Björklund ÅK, van Acker A, Rao A, Kokkinou E, Ekoff M, Thomas D, Fauland A, Nilsson G, Wheelock CE, Dahlén E, Ferreirós N, Geisslinger G, Friberg D, Heinemann A, Konya V and Mjösberg J. Cytokine-induced endogenous production of PGD2 is essential for human ILC2 activation. J Allergy Clin Immunol (JACI). 2019 Jun; 143(6):2202-2214.
4. Konya V, Czarnewski P, Rao A, Forkel M, Villablanca E, Almer S, Lindforss U, Friberg D, Höög C, Bergman P and Mjösberg J. Vitamin D downregulates the IL-23 receptor pathway in human mucosal ILC3. J Allergy Clin Immunol (JACI). 2018 Jan; 141(1):279-292.
5. Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, Sandberg R, Mjösberg J. The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA-sequencing. Nat Immunol. 2016. 17(4):451-60.