Dynamics of gut metabolome and microbiota maturation during early life 

Anna-Katariina Aatsinki et al.

iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21.

Published on November 24, 2025

Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This Read more

Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation 

Thinh Thi Kim Truong et al.

J Oral Biosci. 2025 Dec;67(4):100691. doi: 10.1016/j.job.2025.100691. Epub 2025 Aug 19.

Published on November 22, 2025

CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression Read more

Hepatic zonation determines tumorigenic potential of mutant β-catenin 

Alexander Raven et al.

Nature. 2025 Nov 19. doi: 10.1038/s41586-025-09733-1. Online ahead of print.

Published on November 19, 2025

Oncogenic mutations in phenotypically normal tissue are common across adult organs^(1,2). This suggests that multiple events need to converge to drive tumorigenesis and that many Read more

Breast cancer remodels lymphatics in sentinel lymph nodes 

Dominik Eichin et al.

Nat Commun. 2025 Nov 17;16(1):10056. doi: 10.1038/s41467-025-64981-z.

Published on November 17, 2025

Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis Read more

LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation 

Ubaid Ullah Kalim et al.

iScience. 2025 Oct 15;28(11):113779. doi: 10.1016/j.isci.2025.113779. eCollection 2025 Nov 21.

Published on November 17, 2025

Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and Read more

Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration 

António G G Sousa et al.

Nucleic Acids Res. 2025 Nov 13;53(21):gkaf1128. doi: 10.1093/nar/gkaf1128.

Published on November 16, 2025

Complex single-cell analyses now routinely integrate multiple datasets, followed by cell-type annotation and differential expression analysis. Current state-of-the-art integration methods often struggle with imbalanced cell Read more

Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis 

Tiit Örd et al.

Cardiovasc Res. 2025 Nov 7:cvaf210. doi: 10.1093/cvr/cvaf210. Online ahead of print.

Published on November 9, 2025

CONCLUSIONS: Our findings provide novel insights into macrophage-specific gene programs during atherosclerosis progression and identify a set of promising biomarkers that can serve as a Read more

Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma 

Jie Bao et al.

Biomed Pharmacother. 2025 Nov 6;193:118716. doi: 10.1016/j.biopha.2025.118716. Online ahead of print.

Published on November 7, 2025

Ovarian high-grade serous cancer (HGSC) is the most aggressive ovarian cancer subtype with limited treatment options. We identify the PDPK1 inhibitor BX-912 as a promising Read more

Nextpie: a web-based reporting tool and database for reproducible nextflow pipelines 

Bishwa Ghimire et al.

Bioinform Adv. 2025 Oct 10;5(1):vbaf252. doi: 10.1093/bioadv/vbaf252. eCollection 2025.

Published on November 3, 2025

MOTIVATION: High-throughput genomic data analysis consists of the inexorably intertwined inputs and outputs of a vast array of bioinformatic analysis tools. To guarantee streamlined and Read more

Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal-Amplifying Fluidic Biomimetic Hydrogel 

Yingji Mao et al.

Adv Sci (Weinh). 2025 Oct 15:e16398. doi: 10.1002/advs.202516398. Online ahead of print.

Published on October 15, 2025

Cranial stem cell niches (SCNs) are intrinsically scarce and hypoactive, and, exacerbated by chronic inflammation in diabetes, lead to niche failure and regenerative deficit after Read more

Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study 

Aaron Barron et al.

Lancet Planet Health. 2025 Oct 9:101309. doi: 10.1016/j.lanplh.2025.101309. Online ahead of print.

Published on October 12, 2025

BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants associated with adverse health outcomes in humans. Although they are associated with autism spectrum Read more

Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity 

Prince Dadson et al.

Obesity (Silver Spring). 2025 Oct 12. doi: 10.1002/oby.70041. Online ahead of print.

Published on October 12, 2025

CONCLUSIONS: These findings demonstrate significant molecular alterations in the VAT proteome associated with severe obesity, providing insights into the underlying mechanisms of metabolic disease. The Read more