Publications

Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells

Jun-Nian Zhou et al.

Smart Med. 2025 Feb 26;4(1):e134. doi: 10.1002/smmd.134. eCollection 2025 Mar.

Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial transplantation shows great potential for therapeutic use in treating these diseases. However, transplantation process is notably challenging due to very low efficiency and rapid loss of bioactivity post-isolation, leading to poor reproducibility and reliability. In this study,...

Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study

Mahmoud Bazina et al.

Acta Oncol. 2025 Mar 4;64:339-348. doi: 10.2340/1651-226X.2025.42202.

BACKGROUND AND PURPOSE: Knowledge regarding the risk factors for early death in patients with head and neck squamous cell carcinoma (HNSCC) is scarce. This study aims to evaluate the rate of early death (during or within 6 months of treatment) and its associated risk factors in HNSCC patients treated with curative intent.

A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV

Beston Hamasur et al.

Res Sq [Preprint]. 2025 Feb 18:rs.3.rs-5386988. doi: 10.21203/rs.3.rs-5386988/v2.

CONCLUSIONS: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease

Robert Moulder et al.

Diabetologia. 2025 Jun;68(6):1108-1114. doi: 10.1007/s00125-025-06394-7. Epub 2025 Feb 28.

CONCLUSIONS/INTERPRETATION: The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose ratios in the first year after diagnosis is likely to relate to lipid abnormalities observed in individuals with type 1 diabetes, and reiterates the connection of apolipoproteins with the underlying changes accompanying the disease. Further research is needed to explore the clinical...

Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma

Linda Nissi et al.

Acta Otolaryngol. 2025 Apr;145(4):340-347. doi: 10.1080/00016489.2025.2461653. Epub 2025 Feb 10.

CONCLUSIONS AND SIGNIFICANCE: Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, a discordant group does exist. Limiting HPV-DNA testing for p16-positive patients who smoke by the time of diagnosis may be a cost-efficient and justified solution.

Exploring the physicochemical interactions and loading strategies of mesoporous silicon dioxide nanoparticles for drug delivery

Svetlana Yu Kovtareva et al.

Eur J Pharm Biopharm. 2025 Mar;208:114654. doi: 10.1016/j.ejpb.2025.114654. Epub 2025 Feb 3.

Mesoporous silica nanoparticles play an important role in drug delivery due to their high surface area, porous structure, tunable pore size, chemical stability and functionalization capability. Such properties make them a good candidate for drug encapsulation. However, molecular binding is another parameter that govern drug loading apart of pores' structure and size. There is a lack of comprehensive reviews on that topic nowadays. This paper overviews the latest publications on the...