Publications

    All Publications (240)

    Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids 
    Toni Laine et al. Chembiochem. 2025 Mar 15;26(6):e202400908. doi: 10.1002/cbic.202400908. Epub 2024 Nov 28. Published November 15, 2024
    Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide...
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    Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients 
    Annamaria Petrilla et al. Sci Rep. 2024 Nov 8;14(1):27179. doi: 10.1038/s41598-024-78102-1. Published November 8, 2024
    Shotgun metabarcoding was conducted to examine the microbiota in a total of 48 samples from 12 critically ill patients, analyzing samples from both the oropharynx...
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    The Proteomics Standards Initiative Standardized Formats for Spectral Libraries and Fragment Ion Peak Annotations: mzSpecLib and mzPAF 
    Joshua Klein et al. Anal Chem. 2024 Nov 19;96(46):18491-18501. doi: 10.1021/acs.analchem.4c04091. Epub 2024 Nov 8. Published November 8, 2024
    Mass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream...
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    Expanding the Molecular and Clinical Phenotype of Patients With De Novo Variants in KIF5C: A Six Patient Case Series 
    Sara Gracie et al. Am J Med Genet A. 2025 Mar;197(3):e63927. doi: 10.1002/ajmg.a.63927. Epub 2024 Nov 6. Published November 6, 2024
    Heterozygous de novo loss of function variants in the motor domain of KIF5C are associated with a neurodevelopmental disorder characterized by infantile-onset epilepsy, frontal cortical...
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    Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors 
    Abraham Kuri Cruz et al. Metabolomics. 2024 Nov 4;20(6):125. doi: 10.1007/s11306-024-02185-0. Published November 4, 2024
    CONCLUSION: This collaborative exercise emphasized the broad chemical survey possible with multi-technique approaches. Community engagement is essential for the evaluation and characterization of common materials...
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    xCT as a Predictor for Survival in a Population-Based Cohort of Head and Neck Squamous Cell Carcinoma 
    Linda Nissi et al. Cancer Med. 2024 Nov;13(21):e70371. doi: 10.1002/cam4.70371. Published November 2, 2024
    CONCLUSIONS: High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value...
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    Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy 
    Afonso Mendes et al. Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-5182329. doi: 10.21203/rs.3.rs-5182329/v1. Published November 1, 2024
    From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While superresolution microscopy can...
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    Imaging cell architecture and dynamics 
    Lucy Collinson et al. J Cell Sci. 2024 Oct 15;137(20):jcs263575. doi: 10.1242/jcs.263575. Epub 2024 Oct 30. Published October 30, 2024
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    Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer 
    Karolina Punovuori et al. Cell. 2024 Dec 12;187(25):7267-7284.e20. doi: 10.1016/j.cell.2024.09.046. Epub 2024 Oct 28. Published October 29, 2024
    Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly...
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    Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy 
    Yonghui Wang et al. Nanoscale. 2024 Nov 21;16(45):20925-20939. doi: 10.1039/d4nr02471k. Published October 29, 2024
    M2-type macrophages (M2Φ) play a pro-tumorigenic role and are closely associated with tumor development, where metabolic dysregulation exacerbates the immunosuppressive tumor microenvironment and fosters tumor...
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    Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging 
    Miika Niemeläinen et al. Biol Open. 2024 Nov 15;13(11):bio060428. doi: 10.1242/bio.060428. Epub 2024 Nov 11. Published October 21, 2024
    Routine histochemical techniques are capable of producing vast amount of information from diverse sample types, but these techniques are limited in their ability to generate...
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    Empirically establishing drug exposure records directly from untargeted metabolomics data 
    Haoqi Nina Zhao et al. bioRxiv [Preprint]. 2024 Oct 26:2024.10.07.617109. doi: 10.1101/2024.10.07.617109. Published October 17, 2024
    Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based...
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