Publications

    All Publications (242)

    Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights 
    Akseli Kehusmaa et al. J Pathol. 2026 Jun 18. doi: 10.1002/path.70087. Online ahead of print. Published June 18, 2026
    Tumor border configuration influences colorectal cancer (CRC) prognosis, yet its molecular determinants remain unclear and existing assessment criteria have faced challenges with reproducibility. We introduce...
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    Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling 
    Tuomas Sipilä et al. J Clin Invest. 2026 Jun 15;136(12):e190552. doi: 10.1172/JCI190552. eCollection 2026 Jun 15. Published June 15, 2026
    The blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic...
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    Prognostic role of histological depth of invasion in T1-2 oropharyngeal squamous cell carcinoma 
    Linda Nissi et al. Am J Otolaryngol. 2026 Jun 10;47(4):104869. doi: 10.1016/j.amjoto.2026.104869. Online ahead of print. Published June 12, 2026
    CONCLUSION: DOI was not a prognostic factor in p16-positive T1-2 OPSCC. Nevertheless, DOI may hold prognostic relevance for p16-negative disease. The patterns of local invasion...
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    PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes 
    João Marcos G Barbosa et al. Environ Int. 2026 May 29;213:110337. doi: 10.1016/j.envint.2026.110337. Online ahead of print. Published May 30, 2026
    Per- and polyfluoroalkyl substances (PFAS) are highly persistent environmental pollutants that bioaccumulate in living organisms and are increasingly implicated in metabolic dysfunction-associated steatotic liver disease...
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    Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up 
    Angelica P Ahrens et al. mSystems. 2026 May 28:e0142425. doi: 10.1128/msystems.01424-25. Online ahead of print. Published May 28, 2026
    Childhood obesity is rising globally. Yet, few studies have examined the microbiome and proteome in early childhood in relation to this outcome, and most are...
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    Clarifying the scope and capabilities of ROTS in differential expression analysis 
    Tomi Suomi et al. Bioinformatics. 2026 May 22:btag335. doi: 10.1093/bioinformatics/btag335. Online ahead of print. Published May 24, 2026
    SUMMARY: Recently, Anwar et al. introduced a method combining the ROTS reproducibility optimisation procedure with empirical Bayes variance estimation from limma. Here, we clarify several...
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    Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep 
    Wei Ba et al. Curr Biol. 2026 May 19:S0960-9822(26)00529-4. doi: 10.1016/j.cub.2026.04.059. Online ahead of print. Published May 20, 2026
    How the brain compensates for sleep deprivation (SD) by generating recovery sleep (RS) is not understood. Using Ca²⁺ photometry, we identified a WAKE/rapid eye movement...
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    Joint modeling of longitudinal and time-to-event data for dynamic disease risk prediction using proteomics 
    Markus Lindén et al. Protein Sci. 2026 Jun;35(6):e70621. doi: 10.1002/pro.70621. Published May 18, 2026
    Biomedical studies increasingly incorporate longitudinal data, enabling us to track individual disease processes over time at the molecular level, and to discover associations of the...
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    Association between infant and toddler gut microbiota composition and later executive functioning 
    Venla Huovinen et al. Dev Psychopathol. 2026 May 8:1-15. doi: 10.1017/S0954579426101527. Online ahead of print. Published May 8, 2026
    CONCLUSIONS: Alpha diversity in infancy was negatively associated with preschool EF. Additionally, EFs differed between microbial groups based on dominant genera. Bacterial genera abundances were...
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    Novel CRISPR-Cas9 BAP1 knockout pre-clinical tumor model recapitulates human melanoma tumorigenesis and immune evolution 
    Mona M Wang et al. Commun Biol. 2026 May 5. doi: 10.1038/s42003-026-10118-x. Online ahead of print. Published May 5, 2026
    BAP1-deficient melanocytic tumors exhibit strong immunosuppressive features and poor prognosis. Currently, no immune-competent preclinical models exist to study their tumor-immune interactions or test new immunotherapies....
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    Gene-programmed micro-nano metabolic engine drives coupled osteogenic-angiogenic regeneration 
    Wu Yang et al. Biomaterials. 2026 Apr 28;334:124255. doi: 10.1016/j.biomaterials.2026.124255. Online ahead of print. Published May 5, 2026
    Effective bone healing is accompanied by coupled osteogenic-angiogenic regeneration, a process that critically depends on metabolic communication between bone marrow mesenchymal stem cells (BMSCs) and...
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    Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation 
    James T Grist et al. J Neuroinflammation. 2026 May 4. doi: 10.1186/s12974-026-03839-7. Online ahead of print. Published May 4, 2026
    Given the prevalence of metabolic perturbations in a variety of neurological and neurodegenerative diseases, understanding and monitoring brain metabolism is a key step in our...
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