The Research Council of Finland awarded an infrastructure grant to the Turku Screening Unit as a part of the EU-OPENSCREEN-FINLAND consortium. The funding awarded to the Turku Screening Unit is to establish a single objective light sheet system in 2024, as part of the services at the facility.

Physiological cell-based disease models are becoming increasingly available. However these are 3 dimentional multicellular systems with complex and heterogenous dynamics. Conventional 3D imaging uses highly phototoxic confocal approaches that illuminate the entire depth of a sample every time a single slice is imaged, thereby precluding longitudinal analyses. Light sheet systems avoid this problem but typically involve inconvenient sample suspension between multiple objectives, which compromises multi-sample analysis and precludes screening.

The single-objective light sheet design uses a conventional microscope stage, moves the optical complexities beneath the stage, providing a far more convenient, accessible and photon-efficient system for rapid 3D imaging the dynamics of complex cell systems.

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