Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

    Partho Sen, Syed Bilal Ahmad Andrabi, Tanja Buchacher, Mohd Moin Khan, Ubaid Ullah Kalim, Tuomas Mikael Lindeman, Marina Amaral Alves, Victoria Hinkkanen, Esko Kemppainen, Alex M. Dickens, Omid Rasool, Tuulia Hyötyläinen, Riitta Lahesmaa, Matej Orešič

    Cell Reports (2021)

    Published on December 3, 2025

    DOI: https://doi.org/10.1016/j.celrep.2021.109973

    Core: Metabolomics
    ← Back to Publications
    User Publication
    <i>Staphylococcus aureus</i> Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
    M. Gluud et al. • 2026 • Allergy
    Core:Cytometry Core
    User Publication
    Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
    G. Follain et al. • 2026 • The EMBO Journal
    Core:Advanced Imaging Core
    User Publication
    Synthesis and Characterization of Glyco‐Decorated Silsesquioxane‐Metallosalen Complexes
    H. Haapsaari et al. • 2026 • ChemistrySelect
    Core:Protein Structure and Chemistry
    User Publication
    Functional characterization and directed evolution of Cicer arietinum glutathione transferases for enhanced hydroperoxidase activity and ligandin function
    A. Kontouri et al. • 2026 • Phytochemistry
    Core:Protein Structure and Chemistry
    User Publication
    Isomeric cues direct macrocycle selection from complex chemical systems for selective separation and recycling
    X. Wang et al. • 2026 • Cell Reports Physical Science
    Core:Protein Structure and Chemistry

    More Publications

    User Publication
    December 3, 2025
    Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis
    Santosh Lamichhane, Alex M Dickens, Partho Sen, Heikki Laurikainen, Faith Borgan, Jaana Suvisaari, Tuulia Hyötyläinen, Oliver Howes, Jarmo Hietala, Matej Orešič Schizophrenia Bulletin (2020)
    Abstract Patients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic comorbidities....
    Read abstract
    User Publication
    December 3, 2025
    Dynamics of the Lipidome in a Colon Simulator
    Matilda Kråkström, Alex M. Dickens, Marina Amaral Alves, Sofia D. Forssten, Arthur C. Ouwehand, Tuulia Hyötyläinen, Matej Orešič, Santosh Lamichhane Metabolites (2023)
    Current evidence suggests that gut microbiome-derived lipids play a crucial role in the regulation of host lipid metabolism. However, not...
    Read abstract