Event Details

19^th November at 12:00
Onsite event
in Presidentti auditorium, BioCity
Autumn 2026 poster

Prof. Gwendalyn Randolph, WashU Medicine, USA
The 3 L’s converge: Lymphoid tissue, lymphatics, and lipoproteins

Host: Sirpa Jalkanen (sirjal@utu.fi)

Coffee and sandwich served at 11:45, first come first serve!

Six PhD researchers and early-career postdocs are welcome to have lunch and discuss with Prof. Randolph after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

Gwendalyn J. Randolph is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Louis, Missouri. Her  research focuses on the trafficking of immune cells and molecular cargo between tissues, lymphatics, and distal organs, and how these processes contribute to chronic inflammatory disease. Her laboratory has defined how monocytes, dendritic cells, macrophages, and lipoproteins migrate through tissues and lymphatic vessels in conditions such as atherosclerosis, psoriasis, Crohn’s disease, and liver inflammation. By combining immunology, imaging, lineage tracing, and single-cell profiling approaches, her lab has revealed mechanisms that regulate immune cell migration, lymphatic transport, and tissue-specific macrophage specialization. More recently, Gwendalyn Randolph’s research has focused on the role of high-density lipoprotein (HDL) trafficking in inflammation and tissue homeostasis. Her group demonstrated that lymphatic and vascular transport pathways are critical for HDL movement between organs and identified a specialized form of intestine-derived HDL that protects the liver from inflammatory injury caused by microbial products. These findings provide new insight into the links between immunity, metabolism, and inflammatory disease, with potential translational applications for cardiovascular, intestinal, and liver disorders. In parallel, her laboratory has trained numerous scientists who have gone on to establish independent research laboratories worldwide.

Selected publications

Shchukina I, Rodriguez-Hernandez CJ, …, Kreisel D, Randolph GJ, Artyomov MN. Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment. Cell Rep. 2026 Apr 22;45(5):117303

Kim A, Alligood DM, …, Hegazy L, Zinselmeyer BH, Brestoff JR, Martin CA, Warner BW, Elgendy B, Randolph GJ. A Gut-Restricted Liver X Receptor Agonist Ameliorates Liver Injury in Experimental Short Bowel Syndrome. Gastroenterology. 2026 May;170(5):1017-1032

Erlich EC, Alayo QA, Kim A, Han J, Mintz RL, Huckstep CG, Ruiz HS, Field RL, Dunning TJ, Saleh LS, Hoofnagle MH, Tumanov AV, Guilak F, Brestoff JR, Czepielewski RS, Randolph GJ. Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis. Nat Immunol. 2025 Oct;26(10):1781-1793

Gallerand A, Han J, Ivanov S, Randolph GJ. Mouse and human macrophages and their roles in cardiovascular health and disease. Nat Cardiovasc Res. 2024 Dec;3(12):1424-1437

Han J, Gallerand A, Erlich EC, …, Finlay CM, Allen JE, Jakubzick CV, Else KJ, Onufer EJ, Zhang N, Randolph GJ. Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species. Nat Immunol. 2024 Jan;25(1):155-165

General information

• Registration is not needed, participation list is circulated in the audience.
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars (BKEM1020; UTU), print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Autumn 2026 image credits to Samuel Svärd: Whole mount immunofluorescent staining of the mouse retina. Image acquired on 3i CSU-W1 Spinning disk with 10x objective.