Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes

    Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen

    Environment International (2026)

    Published on November 12, 2026

    DOI: https://doi.org/10.1016/j.envint.2026.110112

    Core: Metabolomics
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    Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
    M. Gluud et al. • 2026 • Allergy
    ABSTRACT Background Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T‐cell lymphoma...
    Core:Cytometry Core
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    Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis
    H. Nabil et al. • 2026 • Archives of Toxicology
    Core:Finnish Functional Genomics Centre
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    Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort
    K. Pahkala et al. • 2026 • International Journal of Epidemiology
    Core:Finnish Functional Genomics Centre
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    Dynamic landscape of transcription initiation by yeast RNA polymerase I
    O. Parilova et al. • 2026 • Nucleic Acids Research
    Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity...
    Core:Protein Structure and Chemistry
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    Emerging Microbial Lipid Shifts in a Multistage Simulated Gut Inoculated with Human Fecal Microbiota
    I. Tamanna et al. • 2026 • Journal of Proteome Research
    Abstract Food residues that bypass human digestion are further digested by gut microbes, leading to the production of diverse metabolites,...
    Core:Metabolomics
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    Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children
    Santosh Lamichhane, Partho Sen, Alex M. Dickens, Matilda Kråkström, Jorma Ilonen, Johanna Lempainen, Heikki Hyöty, Riitta Lahesmaa, Riitta Veijola, Jorma Toppari, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič Frontiers in Endocrinology (2023)
    Aims/hypothesisAppearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however,...
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