Although chemotherapy-induced bone loss is well-recognized during breast cancer treatment, the underlying mechanism remains to be further elucidated, especially in patients with obesity. In this study, the objective was to…

SUMMARY: We introduce REACTOR, a computational tool designed to detect differential activity of transcriptional regulators and their target genes (regulons) in single-cell RNA-sequencing data. It expands the currently available framework…

The cell nucleus is continuously exposed to external signals, of both chemical and mechanical nature. To ensure proper cellular response, cells need to regulate the transmission, timing and duration of…

No abstract…

CONCLUSIONS: HMOs exhibit age-dependent and structure-specific associations with infant gut microbiota, extending beyond breastfeeding.

CONCLUSIONS: Both prenatal and postnatal maternal distress is associated with human milk metabolites. Human milk may buffer infants from some effects of maternal psychological distress, as increases in key metabolites…

Maintenance of protein homeostasis, also known as proteostasis, is essential for cellular survival under both basal and stress conditions. Proteostasis relies on a coordinated action between molecular chaperones, such as…

Kidney size is sex-dimorphic and regulated by androgens in adult humans and mice. However, the effects of developmental androgen deficiency on kidneys remain elusive. We hypothesized that androgens program future…

The earliest morphologically identifiable dogs are from Europe and date to at least 14,000 years ago^(1-5), although early remains are also found in other regions. The origin of early dogs…