Ecto-5′-nucleotidase (CD73) is a potential new drug target for cancer immunotherapy. Its overexpression is associated with various aggressive cancers, including triple-negative breast cancer (TNBC) and pancreatic cancer, making it a…
Customizable FDM-based zebrafish larvae mold for live imaging
Accurate and reproducible orientation of zebrafish larvae is essential for high-resolution live imaging but remains difficult with standard agarose mounting. Although previous methods have used 3D-printed tools, often fabricated via…
Outcomes and future activities of the ‘Pan-European network in Lipidomics and EpiLipidomics – EpiLipidNET’
BACKGROUND: Lipidomics and its branch epilipidomics are rapidly advancing fields that explore the roles of native and modified lipids (e.g., oxidized, nitrated and halogenated lipid species), respectively, in biological systems.
Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
CONCLUSIONS: SE-producing S. aureus promotes skin barrier impairment in CTCL through cytokine-driven, JAK-dependent repression of structural proteins in keratinocytes. These findings identify microbial-immune crosstalk as a contributor to CTCL skin…
XMD8-92 and JWG-045 exhibit anti-ferroptotic activities, independently of inhibiting ERK5
No abstract…
Rector Widen Visited Our Centre
Åbo Akademi University Rector, Gunilla Widén, visited our Centre on Wednesday, February 25th, to learn more about our research and core facilities services operations and our staff. The visit included…
Molecular Characterization of Extracellular Vesicles From Human B Cell Lymphomas: Methodological Comparison to Vesicles From Patient Serum
Human B cell lymphomas represent a clinically heterogeneous disease group with lack of liquid biomarkers for specific subtype classification. Extracellular vesicles (EVs) hold promises as non-invasive biomarkers, yet their subtype-specific…
Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes
The appearance of diabetes-associated autoantibodies is the first detectable sign of the disease process leading to type 1 diabetes (T1D). Evidence suggests that T1D is a heterogenous disease, where the…
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties
Increased extracellular matrix deposition and stiffness promotes solid tumour progression. Yet, the precise mechanotransduction pathways, especially in less-studied mechanically responsive cancers, remain poorly understood. Here we address this gap using…
Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome
Up to 20% of patients with early-stage oral squamous cell carcinoma (OSCC) develop postoperative relapse, but no parameters currently enable the identification of individuals with poor prognosis. Here, we report…