BAP1-deficient melanocytic tumors exhibit strong immunosuppressive features and poor prognosis. Currently, no immune-competent preclinical models exist to study their tumor-immune interactions or test new immunotherapies. This limitation hinders progress in…
Gene-programmed micro-nano metabolic engine drives coupled osteogenic-angiogenic regeneration
Effective bone healing is accompanied by coupled osteogenic-angiogenic regeneration, a process that critically depends on metabolic communication between bone marrow mesenchymal stem cells (BMSCs) and endothelial cells through an endogenous…
Targeting Sphingosine-1-Phosphate Signaling Attenuates Doxorubicin-Aggravated Bone Loss in Obese Breast Cancer Mice
Although chemotherapy-induced bone loss is well-recognized during breast cancer treatment, the underlying mechanism remains to be further elucidated, especially in patients with obesity. In this study, the objective was to…
Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation
Given the prevalence of metabolic perturbations in a variety of neurological and neurodegenerative diseases, understanding and monitoring brain metabolism is a key step in our advancement of therapies. The details…
REACTOR: REgulon Activity analysis and Comparison Tool for single-cell transcriptOmics Research
SUMMARY: We introduce REACTOR, a computational tool designed to detect differential activity of transcriptional regulators and their target genes (regulons) in single-cell RNA-sequencing data. It expands the currently available framework…
Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton
The cell nucleus is continuously exposed to external signals, of both chemical and mechanical nature. To ensure proper cellular response, cells need to regulate the transmission, timing and duration of…
The role of human milk oligosaccharides in shaping and restoring infant gut microbiota: Population-based cohort study
CONCLUSIONS: HMOs exhibit age-dependent and structure-specific associations with infant gut microbiota, extending beyond breastfeeding.
Pre- and postnatal maternal psychological distress and the metabolomic profile of human milk
CONCLUSIONS: Both prenatal and postnatal maternal distress is associated with human milk metabolites. Human milk may buffer infants from some effects of maternal psychological distress, as increases in key metabolites…
Functional Interplay between Heat Shock Protein 90 (HSP90) and Heat Shock Factors (HSFs)
Maintenance of protein homeostasis, also known as proteostasis, is essential for cellular survival under both basal and stress conditions. Proteostasis relies on a coordinated action between molecular chaperones, such as…