Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Here, we analyzed early-life MCBA…
Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells
Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial transplantation shows great potential for…
A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV
CONCLUSIONS: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.
Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study
BACKGROUND AND PURPOSE: Knowledge regarding the risk factors for early death in patients with head and neck squamous cell carcinoma (HNSCC) is scarce. This study aims to evaluate the rate…
Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease
CONCLUSIONS/INTERPRETATION: The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose ratios in the first year…
Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma
CONCLUSIONS AND SIGNIFICANCE: Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, a discordant group does exist.
Exploring the physicochemical interactions and loading strategies of mesoporous silicon dioxide nanoparticles for drug delivery
Mesoporous silica nanoparticles play an important role in drug delivery due to their high surface area, porous structure, tunable pore size, chemical stability and functionalization capability. Such properties make them…
Nuclear talin-1 provides a bridge between cell adhesion and gene expression
Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 is not restricted to focal…
Liquid and gas-chromatography-mass spectrometry methods for exposome analysis
Mass spectrometry-based methods have become fundamental to exposome research, providing the capability to explore a broad spectrum of chemical exposures. Liquid and gas chromatography coupled with low/high-resolution mass spectrometry (MS)…
Metaproteomics Beyond Databases: Addressing the Challenges and Potentials of De Novo Sequencing
Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within their environments. By directly analyzing proteins, metaproteomics offers insights…