Human papillomavirus (HPV) is a major driver of cervical and other epithelial cancers, with the viral oncoprotein E6 playing a central role in tumorigenesis by promoting degradation of the tumor…
HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion
Breast cancer is hallmarked by phenotypic transitions enabling abnormal cell proliferation and invasion. The stress-protective transcription factor heat shock factor 2 (HSF2) is associated with cancer, but its function in…
Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index
Breast milk proteome comprises hundreds of bioactive proteins supporting infant development. The extent to which maternal metabolic conditions modify the proteome is poorly known. This study investigates proteome evolution from…
Metabolome informs about the chemical exposome and links to brain health
The metabolome is an intermediate phenotype, summarizing the profile of all small molecules (…
Designing Fluorescent Estrogen Mimetic 7-hydroxycoumarin Probe Substrates for Human Sulfotransferase Enzymes
Sulfonation is one of drug metabolism reactions affecting homeostasis of estrogens. C-3 aryl substituted 7-hydroxycoumarins are fluorescent estrogen mimetics; i.e., the hydroxyl groups of both estrogens and 7-hydroxycoumarins are conjugated…
Cholesterol Ester Storage Disease in Two Field Spaniels With Lysosomal Acid Lipase Deficiency
Cholesterol ester storage disease (CESD) is a rare genetic lysosomal storage disorder resulting from lower lysosomal acid lipase (LAL) activity. LAL is an essential enzyme required in intracellular lipid metabolism,…
The impact of conjugation strategies and linker density on the performance of the Spermine-AcDex nanoparticle-splenocyte conjugate
A common approach in living medicine engineering is modifying cell surfaces with nanomedicines to form nanoparticle-cell conjugates. Despite various available strategies, limited research has examined how conjugation strategies affect the…
A systematic approach to study the effects of acquisition parameters and biological factors on computerized mammography analysis using ex vivo human tissue: A protocol description
BACKGROUND: Mammography is the most common imaging modality for the detection of breast cancer. Artificial intelligence algorithms for mammography analysis have shown promising performance for breast cancer risk assessment and…
Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat
Deoxynivalenol (DON) is a toxicologically relevant trichothecene mycotoxin frequently found in cereal products. It is a virulence factor produced by the plant pathogen Fusarium graminearum during cereal crop infections. Investigating…
Pharmacokinetics, Metabolism, and Toxicity of Anisomelic Acid and Ovatodiolide: Guiding Route of Administration in Preclinical Studies
Despite extensive progress in cancer therapeutic research, translating promising anticancer compounds into clinical treatments often fails due to suboptimal pharmacokinetic and safety profiles. These shortcomings underscore the critical need for…