Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity
Biochem Biophys Res Commun. 2024 Nov 12;733:150682. doi: 10.1016/j.bbrc.2024.150682. Epub 2024 Sep 10.
Published on September 14, 2024
ABSTRACT
Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as a model to analyze heat stress and effect of chemical compounds on responses to heat stress. The temperature adaptation limit of zebrafish embryos was 37 °C in behavioural test and 38 °C in cardiac test. Polyaromatic hydrocarbon phenanthrene completely blocked the behavioural adaptation to heat stress. Interestingly, the cardiotoxic effects of lapatinib, phenanthrene and paclitaxel were induced by heat stress. Taken together, our data indicates that motility and cardiac function of zebrafish embryos can be utilized as a model to analyze modulatory effects of compounds on heat stress.
PMID:39276696 | DOI:10.1016/j.bbrc.2024.150682
Latest Publications
- The inflammatory path toward type 1 diabetes begins during pregnancy
- Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
- Single-cell RNA-seq analysis of longitudinal CD4+ T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes
- Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies
- PhotoFiTT: a quantitative framework for assessing phototoxicity in live-cell microscopy experiments