Veera K Ojala et al.Mol Oncol. 2025 Dec 23. doi: 10.1002/1878-0261.70189. Online ahead of print.Published December 24, 2025
Receptor tyrosine kinase ERBB4 (HER4) is frequently mutated in human cancer, and ERBB4 mutations have been identified in patients relapsing on targeted therapy. Here, we... Read more
Mario Del Rosario et al.Nat Commun. 2025 Dec 13. doi: 10.1038/s41467-025-66209-6. Online ahead of print.Published December 13, 2025
Phototoxicity in live-cell fluorescence microscopy can compromise experimental outcomes, yet quantitative methods to assess its impact remain limited. Here, we present PhotoFiTT (Phototoxicity Fitness Time... Read more
Haoqi Nina Zhao et al.Nat Commun. 2025 Dec 9;16(1):10600. doi: 10.1038/s41467-025-65993-5.Published December 9, 2025
Despite extensive efforts, extracting medication exposure information from clinical records remains challenging. To complement this approach, here we show the Global Natural Product Social Molecular... Read more
Santosh Lamichhane et al.Nat Commun. 2025 Dec 3. doi: 10.1038/s41467-025-66619-6. Online ahead of print.Published December 3, 2025
Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health... Read more
Chengcheng Li et al.Adv Mater. 2025 Dec 1:e13757. doi: 10.1002/adma.202513757. Online ahead of print.Published December 2, 2025
Despite advances in combination therapies for cancer treatment, most strategies rely on modular-additive designs that lack dynamic molecular cues to achieve intrinsic synergy. Herein, a... Read more
Martina Lerche et al.J Cell Biol. 2026 Feb 2;225(2):e202508155. doi: 10.1083/jcb.202508155. Epub 2025 Dec 2.Published December 2, 2025
Constitutive integrin endocytosis and recycling control cell movement and morphology. In contrast, the role of newly synthesized integrins delivered via the biosynthetic pathway has been... Read more
Ye Hong et al.Neurobiol Dis. 2025 Nov 29;218:107207. doi: 10.1016/j.nbd.2025.107207. Online ahead of print.Published November 30, 2025
c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo... Read more
Yu Zhang et al.Adv Mater. 2025 Nov 28:e18378. doi: 10.1002/adma.202518378. Online ahead of print.Published November 28, 2025
The positive feedback circuit between the complement system and inflammatory immune responses maps the malignant progression of chronic joint inflammation. Prolonged dysregulation of the immune... Read more
Sepideh Parvanian et al.Eur J Cell Biol. 2025 Nov 21;104(4):151523. doi: 10.1016/j.ejcb.2025.151523. Online ahead of print.Published November 27, 2025
Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of... Read more
Charoutioun S Bodourian et al.Protein Sci. 2025 Dec;34(12):e70396. doi: 10.1002/pro.70396.Published November 26, 2025
The 16S microbial community profiling of a metagenomics library from geothermal spring at Lisvori (Lesvos island, Greece) enabled the identification of a putative sequence exhibiting... Read more
Shrikant B Kokate et al.Curr Biol. 2025 Nov 25:S0960-9822(25)01462-9. doi: 10.1016/j.cub.2025.10.081. Online ahead of print.Published November 26, 2025
Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their... Read more
Anna-Katariina Aatsinki et al.iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21.Published November 24, 2025
Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This... Read more
