Publications

    Publication
    Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase 
    Charoutioun S Bodourian et al. Protein Sci. 2025 Dec;34(12):e70396. doi: 10.1002/pro.70396. Published November 26, 2025
    The 16S microbial community profiling of a metagenomics library from geothermal spring at Lisvori (Lesvos island, Greece) enabled the identification of a putative sequence exhibiting... Read more
    Publication
    Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles 
    Shrikant B Kokate et al. Curr Biol. 2025 Nov 25:S0960-9822(25)01462-9. doi: 10.1016/j.cub.2025.10.081. Online ahead of print. Published November 26, 2025
    Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their... Read more
    Publication
    Dynamics of gut metabolome and microbiota maturation during early life 
    Anna-Katariina Aatsinki et al. iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21. Published November 24, 2025
    Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This... Read more
    Publication
    Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation 
    Thinh Thi Kim Truong et al. J Oral Biosci. 2025 Dec;67(4):100691. doi: 10.1016/j.job.2025.100691. Epub 2025 Aug 19. Published November 22, 2025
    CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression... Read more
    Publication
    Hepatic zonation determines tumorigenic potential of mutant β-catenin 
    Alexander Raven et al. Nature. 2025 Nov 19. doi: 10.1038/s41586-025-09733-1. Online ahead of print. Published November 19, 2025
    Oncogenic mutations in phenotypically normal tissue are common across adult organs^(1,2). This suggests that multiple events need to converge to drive tumorigenesis and that many... Read more
    Publication
    LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation 
    Ubaid Ullah Kalim et al. iScience. 2025 Oct 15;28(11):113779. doi: 10.1016/j.isci.2025.113779. eCollection 2025 Nov 21. Published November 17, 2025
    Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and... Read more
    Publication
    Breast cancer remodels lymphatics in sentinel lymph nodes 
    Dominik Eichin et al. Nat Commun. 2025 Nov 17;16(1):10056. doi: 10.1038/s41467-025-64981-z. Published November 17, 2025
    Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis... Read more
    Publication
    Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration 
    António G G Sousa et al. Nucleic Acids Res. 2025 Nov 13;53(21):gkaf1128. doi: 10.1093/nar/gkaf1128. Published November 16, 2025
    Complex single-cell analyses now routinely integrate multiple datasets, followed by cell-type annotation and differential expression analysis. Current state-of-the-art integration methods often struggle with imbalanced cell... Read more
    Publication
    Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis 
    Tiit Örd et al. Cardiovasc Res. 2025 Nov 7:cvaf210. doi: 10.1093/cvr/cvaf210. Online ahead of print. Published November 9, 2025
    CONCLUSIONS: Our findings provide novel insights into macrophage-specific gene programs during atherosclerosis progression and identify a set of promising biomarkers that can serve as a... Read more
    Publication
    Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma 
    Jie Bao et al. Biomed Pharmacother. 2025 Nov 6;193:118716. doi: 10.1016/j.biopha.2025.118716. Online ahead of print. Published November 7, 2025
    Ovarian high-grade serous cancer (HGSC) is the most aggressive ovarian cancer subtype with limited treatment options. We identify the PDPK1 inhibitor BX-912 as a promising... Read more
    Publication
    Nextpie: a web-based reporting tool and database for reproducible nextflow pipelines 
    Bishwa Ghimire et al. Bioinform Adv. 2025 Oct 10;5(1):vbaf252. doi: 10.1093/bioadv/vbaf252. eCollection 2025. Published November 3, 2025
    MOTIVATION: High-throughput genomic data analysis consists of the inexorably intertwined inputs and outputs of a vast array of bioinformatic analysis tools. To guarantee streamlined and... Read more
    Publication
    Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal-Amplifying Fluidic Biomimetic Hydrogel 
    Yingji Mao et al. Adv Sci (Weinh). 2025 Oct 15:e16398. doi: 10.1002/advs.202516398. Online ahead of print. Published October 15, 2025
    Cranial stem cell niches (SCNs) are intrinsically scarce and hypoactive, and, exacerbated by chronic inflammation in diabetes, lead to niche failure and regenerative deficit after... Read more
    Last updated on June 25, 2025