Publications

    All Publications (240)

    Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa 
    Dimitrios V Nokas et al. FEBS J. 2025 Jun 3. doi: 10.1111/febs.70151. Online ahead of print. Published June 3, 2025
    Industrialization and urbanization have caused serious contamination of water bodies, and the removal of chemical contaminants has become a major challenge. Chlorite is a harmful...
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    A guide to heat shock factors as multifunctional transcriptional regulators 
    Hendrik S E Hästbacka et al. FEBS J. 2025 Jun 2. doi: 10.1111/febs.70139. Online ahead of print. Published June 2, 2025
    The heat shock factors (HSFs) form a family of transcription factors, which are evolutionarily conserved in eukaryotes. They are best known as transcriptional regulators of...
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    Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings 
    Emil Rosqvist et al. Nanomaterials (Basel). 2025 May 9;15(10):716. doi: 10.3390/nano15100716. Published May 27, 2025
    The proliferation of human cervical cancer (Hela) cells was investigated on a series of nanostructured polymer latex surfaces. The physico-chemical properties of the surfaces, composed...
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    Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells 
    James R W Conway et al. Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01663-4. Online ahead of print. Published May 26, 2025
    Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized...
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    Mass spectrometric insights into the protein composition of human cutaneous neurofibromas: comparison of neurofibromas with the overlying skin 
    Roope A Kallionpää et al. Br J Cancer. 2025 May 20. doi: 10.1038/s41416-025-03055-9. Online ahead of print. Published May 20, 2025
    CONCLUSION: The cNFs are relatively quiescent, consistent with their benign nature and limited growth potential. The development of pharmacological therapy for cNFs requires overcoming the...
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    High-resolution live imaging of tardigrade response to anoxia 
    Anna-Mari Haapanen-Saaristo et al. Micron. 2025 May 9;196-197:103847. doi: 10.1016/j.micron.2025.103847. Online ahead of print. Published May 14, 2025
    Tardigrades are well-known for their ability to tolerate extreme environmental conditions such as heat, drought and lack of oxygen by undergoing cryptobiosis. The molecular responses...
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    CellRomeR: an R package for clustering cell migration phenotypes from microscopy data 
    Iivari Kleino et al. Bioinform Adv. 2025 Apr 4;5(1):vbaf069. doi: 10.1093/bioadv/vbaf069. eCollection 2025. Published May 7, 2025
    MOTIVATION: The analysis of cell migration using time-lapse microscopy typically focuses on track characteristics for classification and statistical evaluation of migration behaviour. However, considerable heterogeneity...
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    The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans 
    Minna Ampuja et al. HGG Adv. 2025 May 5;6(3):100446. doi: 10.1016/j.xhgg.2025.100446. Online ahead of print. Published May 7, 2025
    Non-syndromic congenital heart defects (CHDs) are occasionally familial and left ventricular outflow tract obstruction (LVOTO) defects are among the subtypes with the highest hereditability. The...
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    HDAC1 is involved in the destabilization of the HSF2 protein under non-stress and stress conditions 
    Kevin Daupin et al. Cell Stress Chaperones. 2025 May 1:100079. doi: 10.1016/j.cstres.2025.100079. Online ahead of print. Published May 3, 2025
    Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and...
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    Longitudinal pathway analysis using structural information with case studies in early type 1 diabetes 
    Maria K Jaakkola et al. Sci Rep. 2025 May 2;15(1):15393. doi: 10.1038/s41598-025-98492-0. Published May 2, 2025
    Pathway analysis is a frequent step in studies involving gene or protein expression data, but most of the available pathway methods are designed for simple...
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    Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes 
    Emil Hiitola et al. Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30. Published April 30, 2025
    Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation...
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    Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma 
    Erica Routila et al. Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717. Published April 27, 2025
    CONCLUSIONS: We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with...
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