Publications

    All Publications (240)

    Mitochondria-Targeted Nanomotor: H2S-Driven Cascade Therapy for Hepatocellular Carcinoma 
    Chengcheng Li et al. Adv Mater. 2025 Dec 1:e13757. doi: 10.1002/adma.202513757. Online ahead of print. Published December 2, 2025
    Despite advances in combination therapies for cancer treatment, most strategies rely on modular-additive designs that lack dynamic molecular cues to achieve intrinsic synergy. Herein, a...
    Read abstract
    Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway 
    Martina Lerche et al. J Cell Biol. 2026 Feb 2;225(2):e202508155. doi: 10.1083/jcb.202508155. Epub 2025 Dec 2. Published December 2, 2025
    Constitutive integrin endocytosis and recycling control cell movement and morphology. In contrast, the role of newly synthesized integrins delivered via the biosynthetic pathway has been...
    Read abstract
    JNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation 
    Ye Hong et al. Neurobiol Dis. 2025 Nov 29;218:107207. doi: 10.1016/j.nbd.2025.107207. Online ahead of print. Published November 30, 2025
    c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo...
    Read abstract
    Disrupting Complement-Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation 
    Yu Zhang et al. Adv Mater. 2025 Nov 28:e18378. doi: 10.1002/adma.202518378. Online ahead of print. Published November 28, 2025
    The positive feedback circuit between the complement system and inflammatory immune responses maps the malignant progression of chronic joint inflammation. Prolonged dysregulation of the immune...
    Read abstract
    Vimentin in the tumor microenvironment: orchestrating invasion, immunity, and metabolism 
    Sepideh Parvanian et al. Eur J Cell Biol. 2025 Nov 21;104(4):151523. doi: 10.1016/j.ejcb.2025.151523. Online ahead of print. Published November 27, 2025
    Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of...
    Read abstract
    Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase 
    Charoutioun S Bodourian et al. Protein Sci. 2025 Dec;34(12):e70396. doi: 10.1002/pro.70396. Published November 26, 2025
    The 16S microbial community profiling of a metagenomics library from geothermal spring at Lisvori (Lesvos island, Greece) enabled the identification of a putative sequence exhibiting...
    Read abstract
    Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles 
    Shrikant B Kokate et al. Curr Biol. 2025 Nov 25:S0960-9822(25)01462-9. doi: 10.1016/j.cub.2025.10.081. Online ahead of print. Published November 26, 2025
    Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their...
    Read abstract
    Dynamics of gut metabolome and microbiota maturation during early life 
    Anna-Katariina Aatsinki et al. iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21. Published November 24, 2025
    Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This...
    Read abstract
    Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation 
    Thinh Thi Kim Truong et al. J Oral Biosci. 2025 Dec;67(4):100691. doi: 10.1016/j.job.2025.100691. Epub 2025 Aug 19. Published November 22, 2025
    CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression...
    Read abstract
    Hepatic zonation determines tumorigenic potential of mutant β-catenin 
    Alexander Raven et al. Nature. 2025 Nov 19. doi: 10.1038/s41586-025-09733-1. Online ahead of print. Published November 19, 2025
    Oncogenic mutations in phenotypically normal tissue are common across adult organs^(1,2). This suggests that multiple events need to converge to drive tumorigenesis and that many...
    Read abstract
    Breast cancer remodels lymphatics in sentinel lymph nodes 
    Dominik Eichin et al. Nat Commun. 2025 Nov 17;16(1):10056. doi: 10.1038/s41467-025-64981-z. Published November 17, 2025
    Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis...
    Read abstract
    LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation 
    Ubaid Ullah Kalim et al. iScience. 2025 Oct 15;28(11):113779. doi: 10.1016/j.isci.2025.113779. eCollection 2025 Nov 21. Published November 17, 2025
    Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and...
    Read abstract