Stress biology: Complexity and multifariousness in health and disease
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
Published on December 10, 2024
ABSTRACT
PMID:38311120 | PMC:PMC10939078 | DOI:10.1016/j.cstres.2024.01.006
Turku Bioscience Centre[Affiliation]
Back to PublicationsLatest Publications
- Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome
- Embigin is involved in the regulation of early mouse kidney development
- Complete Data Analysis Workflow for Quantitative DIA Mass Spectrometry Using Nextflow
- Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
- High-sensitivity, protein-independent detection of dsDNA sequences